FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000211715> ?p ?o ?g. }

• W2000211715 endingPage "1196" @default.
• W2000211715 startingPage "1188" @default.
• W2000211715 abstract "Bisphosphonates are effective for preventing and treating skeletal disorders associated with hyperresorption. Their safety and efficacy has been studied in adults where the growth plate is fused and there is no longitudinal bone growth and little appositional growth. Although bisphosphonate use in the pediatric population was pioneered for compassionate use in the treatment of osteogenesis imperfecta, they are being increasingly used for the treatment and prevention of bone loss in children at risk of hyperresorptive bone loss. However, the effect of these agents on the growing skeleton in disorders other than osteogenesis imperfecta has not been systematically compared. Studies were, therefore, undertaken to examine the consequences of bisphosphonate administration on the growth plate and skeletal microarchitecture during a period of rapid growth. C57Bl6/J male mice were treated from 18 to 38 days of age with vehicle, alendronate, pamidronate, zoledronate, or clodronate at doses selected to replicate those used in humans. Treatment with alendronate, pamidronate, and zoledronate, but not clodronate, led to a decrease in the number of chondrocytes per column in the hypertrophic chondrocyte layer. This was not associated with altered hypertrophic chondrocyte apoptosis or vascular invasion at the growth plate. The effects of pamidronate on trabecular microarchitecture were less beneficial than those of alendronate and zoledronate. Pamidronate did not increase cortical thickness or cortical area/total area relative to control mice. These studies suggest that bisphosphonate administration does not adversely affect skeletal growth. Long-term investigations are required to determine whether the differences observed among the agents examined impact biomechanical integrity of the growing skeleton." @default.
• W2000211715 created "2016-06-24" @default.
• W2000211715 creator A5032638450 @default.
• W2000211715 creator A5047425621 @default.
• W2000211715 creator A5058515618 @default.
• W2000211715 creator A5063304744 @default.
• W2000211715 creator A5072227313 @default.
• W2000211715 date "2014-04-01" @default.
• W2000211715 modified "2023-10-06" @default.
• W2000211715 title "Effect of Bisphosphonates on the Rapidly Growing Male Murine Skeleton" @default.
• W2000211715 cites W1545816663 @default.
• W2000211715 cites W1967380126 @default.
• W2000211715 cites W1969921973 @default.
• W2000211715 cites W1970220222 @default.
• W2000211715 cites W1970420277 @default.
• W2000211715 cites W1975447125 @default.
• W2000211715 cites W1990858798 @default.
• W2000211715 cites W1992742436 @default.
• W2000211715 cites W1993006174 @default.
• W2000211715 cites W1993035292 @default.
• W2000211715 cites W1995556654 @default.
• W2000211715 cites W1997982273 @default.
• W2000211715 cites W2001478403 @default.
• W2000211715 cites W2005107495 @default.
• W2000211715 cites W2006776050 @default.
• W2000211715 cites W2007569697 @default.
• W2000211715 cites W2009497740 @default.
• W2000211715 cites W2012194552 @default.
• W2000211715 cites W2018447049 @default.
• W2000211715 cites W2023920419 @default.
• W2000211715 cites W2027033656 @default.
• W2000211715 cites W2033331572 @default.
• W2000211715 cites W2034553603 @default.
• W2000211715 cites W2036285233 @default.
• W2000211715 cites W2038121195 @default.
• W2000211715 cites W2065463926 @default.
• W2000211715 cites W2066749771 @default.
• W2000211715 cites W2074577207 @default.
• W2000211715 cites W2079527690 @default.
• W2000211715 cites W2081417842 @default.
• W2000211715 cites W2085965947 @default.
• W2000211715 cites W2086312238 @default.
• W2000211715 cites W2087848685 @default.
• W2000211715 cites W2124527463 @default.
• W2000211715 cites W2126838017 @default.
• W2000211715 cites W2131094566 @default.
• W2000211715 cites W2156299130 @default.
• W2000211715 cites W2158739925 @default.
• W2000211715 cites W2166105421 @default.
• W2000211715 cites W2229493280 @default.
• W2000211715 cites W2270086446 @default.
• W2000211715 cites W2321227665 @default.
• W2000211715 cites W2329575366 @default.
• W2000211715 cites W4236608613 @default.
• W2000211715 cites W4251795098 @default.
• W2000211715 doi "https://doi.org/10.1210/en.2013-1993" @default.
• W2000211715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3959604" @default.
• W2000211715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24422540" @default.
• W2000211715 hasPublicationYear "2014" @default.
• W2000211715 type Work @default.
• W2000211715 sameAs 2000211715 @default.
• W2000211715 citedByCount "22" @default.
• W2000211715 countsByYear W20002117152014 @default.
• W2000211715 countsByYear W20002117152015 @default.
• W2000211715 countsByYear W20002117152016 @default.
• W2000211715 countsByYear W20002117152017 @default.
• W2000211715 countsByYear W20002117152018 @default.
• W2000211715 countsByYear W20002117152019 @default.
• W2000211715 countsByYear W20002117152020 @default.
• W2000211715 countsByYear W20002117152021 @default.
• W2000211715 countsByYear W20002117152023 @default.
• W2000211715 crossrefType "journal-article" @default.
• W2000211715 hasAuthorship W2000211715A5032638450 @default.
• W2000211715 hasAuthorship W2000211715A5047425621 @default.
• W2000211715 hasAuthorship W2000211715A5058515618 @default.
• W2000211715 hasAuthorship W2000211715A5063304744 @default.
• W2000211715 hasAuthorship W2000211715A5072227313 @default.
• W2000211715 hasBestOaLocation W20002117151 @default.
• W2000211715 hasConcept C105702510 @default.
• W2000211715 hasConcept C126322002 @default.
• W2000211715 hasConcept C134018914 @default.
• W2000211715 hasConcept C142724271 @default.
• W2000211715 hasConcept C17938293 @default.
• W2000211715 hasConcept C18969341 @default.
• W2000211715 hasConcept C2776541429 @default.
• W2000211715 hasConcept C2777251235 @default.
• W2000211715 hasConcept C2777668750 @default.
• W2000211715 hasConcept C2780550940 @default.
• W2000211715 hasConcept C2781403057 @default.
• W2000211715 hasConcept C2781451080 @default.
• W2000211715 hasConcept C2908647359 @default.
• W2000211715 hasConcept C2991750140 @default.
• W2000211715 hasConcept C71924100 @default.
• W2000211715 hasConcept C99454951 @default.
• W2000211715 hasConceptScore W2000211715C105702510 @default.
• W2000211715 hasConceptScore W2000211715C126322002 @default.
• W2000211715 hasConceptScore W2000211715C134018914 @default.
• W2000211715 hasConceptScore W2000211715C142724271 @default.

• next