Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000211838> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2000211838 endingPage "348" @default.
- W2000211838 startingPage "339" @default.
- W2000211838 abstract "An accumulation of Na+ is induced in the ischemic myocardium, which is so-called Na+ overload. The exact role of Na+ overload in the genesis of myocardial ischemia/reperfusion injury remains unclear except for the role as a driving force of Ca2+ overload in the reperfused myocardium. Excessive activation of Na+/H+ exchanger (NHE) and Na+ channels may contribute to Na+ influx into the ischemic myocardium, resulting in sodium overload under ischemic conditions. A decrease in energy-producing ability of mitochondria in the ischemic myocardium is also observed in an ischemic duration-dependent manner. Attenuation of Na+ overload by an NHE inhibitor or a Na+ channel blocker preserved mitochondrial energy production in the ischemic myocardium and enhanced post-ischemic contractile recovery. To mimic Na+ overload in the ischemic myocardium, isolated mitochondria were incubated with sodium lactate, a possible end product of anaerobic glycolysis. Sodium lactate induced an irreversible reduction in the mitochondrial energy production. The mitochondrial damage induced by sodium lactate was not attenuated by the NHE inhibitor or the Na+ channel blocker, suggesting that these agents may indirectly preserve mitochondrial function in the ischemic myocardium. Taken together, Na+ overload in the ischemic myocardium may induce mitochondrial dysfunction, leading to contractile failure of the reperfused myocardium." @default.
- W2000211838 created "2016-06-24" @default.
- W2000211838 creator A5009749245 @default.
- W2000211838 creator A5090943443 @default.
- W2000211838 date "2003-01-01" @default.
- W2000211838 modified "2023-10-04" @default.
- W2000211838 title "Na+ overload-induced mitochondrial dysfunction in myocardial ischemia/reperfusion injury" @default.
- W2000211838 cites W1933882513 @default.
- W2000211838 cites W1969012706 @default.
- W2000211838 cites W1978655987 @default.
- W2000211838 cites W1983165225 @default.
- W2000211838 cites W1994960681 @default.
- W2000211838 cites W2000298437 @default.
- W2000211838 cites W2003730105 @default.
- W2000211838 cites W2012106712 @default.
- W2000211838 cites W2022330306 @default.
- W2000211838 cites W2047563687 @default.
- W2000211838 cites W2059371054 @default.
- W2000211838 cites W2059483340 @default.
- W2000211838 cites W2065228495 @default.
- W2000211838 cites W2071594464 @default.
- W2000211838 cites W2073915084 @default.
- W2000211838 cites W2088192454 @default.
- W2000211838 cites W2105945127 @default.
- W2000211838 cites W2114457659 @default.
- W2000211838 cites W2127976720 @default.
- W2000211838 cites W2268175810 @default.
- W2000211838 cites W2319950355 @default.
- W2000211838 cites W2331434884 @default.
- W2000211838 cites W4248009949 @default.
- W2000211838 cites W70713144 @default.
- W2000211838 doi "https://doi.org/10.1254/fpj.121.339" @default.
- W2000211838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12784736" @default.
- W2000211838 hasPublicationYear "2003" @default.
- W2000211838 type Work @default.
- W2000211838 sameAs 2000211838 @default.
- W2000211838 citedByCount "1" @default.
- W2000211838 crossrefType "journal-article" @default.
- W2000211838 hasAuthorship W2000211838A5009749245 @default.
- W2000211838 hasAuthorship W2000211838A5090943443 @default.
- W2000211838 hasBestOaLocation W20002118381 @default.
- W2000211838 hasConcept C114574056 @default.
- W2000211838 hasConcept C126322002 @default.
- W2000211838 hasConcept C164705383 @default.
- W2000211838 hasConcept C178790620 @default.
- W2000211838 hasConcept C185592680 @default.
- W2000211838 hasConcept C20251656 @default.
- W2000211838 hasConcept C2779311647 @default.
- W2000211838 hasConcept C28859421 @default.
- W2000211838 hasConcept C42407357 @default.
- W2000211838 hasConcept C50952357 @default.
- W2000211838 hasConcept C5140985 @default.
- W2000211838 hasConcept C537181965 @default.
- W2000211838 hasConcept C541997718 @default.
- W2000211838 hasConcept C55493867 @default.
- W2000211838 hasConcept C62231903 @default.
- W2000211838 hasConcept C71924100 @default.
- W2000211838 hasConceptScore W2000211838C114574056 @default.
- W2000211838 hasConceptScore W2000211838C126322002 @default.
- W2000211838 hasConceptScore W2000211838C164705383 @default.
- W2000211838 hasConceptScore W2000211838C178790620 @default.
- W2000211838 hasConceptScore W2000211838C185592680 @default.
- W2000211838 hasConceptScore W2000211838C20251656 @default.
- W2000211838 hasConceptScore W2000211838C2779311647 @default.
- W2000211838 hasConceptScore W2000211838C28859421 @default.
- W2000211838 hasConceptScore W2000211838C42407357 @default.
- W2000211838 hasConceptScore W2000211838C50952357 @default.
- W2000211838 hasConceptScore W2000211838C5140985 @default.
- W2000211838 hasConceptScore W2000211838C537181965 @default.
- W2000211838 hasConceptScore W2000211838C541997718 @default.
- W2000211838 hasConceptScore W2000211838C55493867 @default.
- W2000211838 hasConceptScore W2000211838C62231903 @default.
- W2000211838 hasConceptScore W2000211838C71924100 @default.
- W2000211838 hasIssue "5" @default.
- W2000211838 hasLocation W20002118381 @default.
- W2000211838 hasLocation W20002118382 @default.
- W2000211838 hasOpenAccess W2000211838 @default.
- W2000211838 hasPrimaryLocation W20002118381 @default.
- W2000211838 hasRelatedWork W1866831778 @default.
- W2000211838 hasRelatedWork W1982007667 @default.
- W2000211838 hasRelatedWork W1997657673 @default.
- W2000211838 hasRelatedWork W2066853893 @default.
- W2000211838 hasRelatedWork W2068978451 @default.
- W2000211838 hasRelatedWork W2112831037 @default.
- W2000211838 hasRelatedWork W2120710688 @default.
- W2000211838 hasRelatedWork W2133077169 @default.
- W2000211838 hasRelatedWork W2139141364 @default.
- W2000211838 hasRelatedWork W2609626597 @default.
- W2000211838 hasVolume "121" @default.
- W2000211838 isParatext "false" @default.
- W2000211838 isRetracted "false" @default.
- W2000211838 magId "2000211838" @default.
- W2000211838 workType "article" @default.