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- W2000212424 abstract "Inner ear damage leads to nerve fiber growth and synaptogenesis in the ventral cochlear nucleus (VCN). In this study, we documented the relationship between hair cell loss patterns and synaptic plasticity in the chinchilla VCN using immunolabeling of the growth associated protein-43 (GAP-43), a protein associated with axon outgrowth and modification of presynaptic endings. Unilateral round window application of carboplatin caused hair cell degeneration in which inner hair cells (IHC) were more vulnerable than outer hair cells (OHC). One month after carboplatin treatment (0.5-5 mg/ml), we observed varying patterns of cochlear hair cell loss and GAP-43 expression in VCN. Both IHC loss and OHC loss were strongly correlated with increased GAP-43 immunolabeling in the ipsilateral VCN. We speculate that two factors might promote the expression of GAP-43 in the VCN; one is the loss of afferent input through IHC or the associated type I auditory nerve fibers. The other occurs when the medial olivocochlear efferent neurons lose their cochlear targets, the OHC, and may as compensation increase their synapse numbers in the VCN." @default.
- W2000212424 created "2016-06-24" @default.
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- W2000212424 date "2013-08-01" @default.
- W2000212424 modified "2023-09-25" @default.
- W2000212424 title "Up-regulation of GAP-43 in the chinchilla ventral cochlear nucleus after carboplatin-induced hearing loss: Correlations with inner hair cell loss and outer hair cell loss" @default.
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- W2000212424 cites W1654314171 @default.
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- W2000212424 cites W18393152 @default.
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- W2000212424 cites W1964248735 @default.
- W2000212424 cites W1966939142 @default.
- W2000212424 cites W1973684876 @default.
- W2000212424 cites W1973941114 @default.
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- W2000212424 cites W1981778268 @default.
- W2000212424 cites W1986131585 @default.
- W2000212424 cites W1992216070 @default.
- W2000212424 cites W1993626595 @default.
- W2000212424 cites W2005316849 @default.
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- W2000212424 cites W2010621092 @default.
- W2000212424 cites W2012284510 @default.
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- W2000212424 cites W2037976268 @default.
- W2000212424 cites W2041460658 @default.
- W2000212424 cites W2043033914 @default.
- W2000212424 cites W2048818224 @default.
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- W2000212424 cites W2054436022 @default.
- W2000212424 cites W2055698404 @default.
- W2000212424 cites W2056630997 @default.
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- W2000212424 cites W2061489132 @default.
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- W2000212424 doi "https://doi.org/10.1016/j.heares.2013.05.002" @default.
- W2000212424 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3905197" @default.
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- W2000212424 hasPublicationYear "2013" @default.
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