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• W2000213570 startingPage "4371" @default.
• W2000213570 abstract "Analysis of cDNA and genomic clones shows that the murine Ig/EBP (C/EBP gamma) gene encodes a small protein with a predicted molecular weight of 16.4 kDa which contains C/EBP family basic and leucine zipper domains but lacks the transcriptional activation domains present in C/EBP (C/EBP alpha) and NF-IL6 (C/EBP beta). In transfection assays Ig/EBP is neither an activator nor a repressor of transcription; however, Ig/EBP inhibits the transcriptional ability of NF-IL6 (C/EBP beta) and C/EBP (C/EBP alpha), acting as a transdominant negative regulator. Thus Ig/EBP resembles LIP, another negative regulator of the C/EBP family, in both structure and transcriptional activity. Of the three known C/EBP family inhibitors, Ig/EBP, LIP and CHOP-10, only Ig/EBP is ubiquitously expressed. Therefore, Ig/EBP may act as a general buffer for C/EBP activators in many cell types." @default.
• W2000213570 created "2016-06-24" @default.
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• W2000213570 date "1995-01-01" @default.
• W2000213570 modified "2023-09-25" @default.
• W2000213570 title "Ig/EBP (C/EBPγ) is a transdominant negative inhibitor of C/EBP family transcriptional activators" @default.
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• W2000213570 doi "https://doi.org/10.1093/nar/23.21.4371" @default.
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