Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000213929> ?p ?o ?g. }
- W2000213929 endingPage "96" @default.
- W2000213929 startingPage "88" @default.
- W2000213929 abstract "The Smad family proteins are critical components of the transforming growth factor (TGF)-beta signaling pathway. TGF-beta is a multipotent cytokine that elicits many biological functions. In particular, TGF-beta exhibits effects on the cell cycle manifested by G1-phase arrest, differentiation, or apoptosis of several target cells, suggesting that disruption of TGF-beta signaling pathway could be involved in cancer formation. Here we show one missense mutation of the Smad4 gene in the MH1 domain (P102L) and one frame shift mutation resulting in termination in the MH2 domain (Delta(483 - 552)) in acute myelogeneous leukemia. Both of the mutated Smad4 proteins lack transcriptional activities. Concomitant expression of the P102L mutant with wild-type Smad4 inactivates wild-type Smad4 through inhibiting its DNA-binding ability. The Delta(483 - 552) mutant blocks nuclear translocation of wild-type Smad4 and thus disrupts TGF-beta signaling. This is the first report showing that mutations in the Smad4 gene are associated with the pathogenesis of acute myelogeneous leukemia and the obtained results should provide useful insights into the mechanism whereby disruption of TGF-beta signaling pathway could lead to acute myelogeneous leukemia. Oncogene (2001) 20, 88 - 96." @default.
- W2000213929 created "2016-06-24" @default.
- W2000213929 creator A5027118202 @default.
- W2000213929 creator A5042588749 @default.
- W2000213929 creator A5050827716 @default.
- W2000213929 creator A5067804516 @default.
- W2000213929 creator A5074188255 @default.
- W2000213929 creator A5084289729 @default.
- W2000213929 creator A5085709435 @default.
- W2000213929 creator A5087133884 @default.
- W2000213929 creator A5088372604 @default.
- W2000213929 date "2001-01-04" @default.
- W2000213929 modified "2023-10-18" @default.
- W2000213929 title "Mutations of the Smad4 gene in acute myelogeneous leukemia and their functional implications in leukemogenesis" @default.
- W2000213929 cites W1481643702 @default.
- W2000213929 cites W1494055834 @default.
- W2000213929 cites W15248648 @default.
- W2000213929 cites W1532921008 @default.
- W2000213929 cites W1533133582 @default.
- W2000213929 cites W1560943589 @default.
- W2000213929 cites W1662963035 @default.
- W2000213929 cites W1663371441 @default.
- W2000213929 cites W1684737398 @default.
- W2000213929 cites W1966507279 @default.
- W2000213929 cites W1984135296 @default.
- W2000213929 cites W1988942273 @default.
- W2000213929 cites W1992468405 @default.
- W2000213929 cites W1995140691 @default.
- W2000213929 cites W1995659612 @default.
- W2000213929 cites W2039458025 @default.
- W2000213929 cites W2039550311 @default.
- W2000213929 cites W2048355846 @default.
- W2000213929 cites W2062007120 @default.
- W2000213929 cites W2084640614 @default.
- W2000213929 cites W2088690410 @default.
- W2000213929 cites W2098097317 @default.
- W2000213929 cites W2100522747 @default.
- W2000213929 cites W2103031848 @default.
- W2000213929 cites W2119727612 @default.
- W2000213929 cites W2136190597 @default.
- W2000213929 cites W2145589640 @default.
- W2000213929 cites W2147213204 @default.
- W2000213929 cites W2164615751 @default.
- W2000213929 cites W2171915984 @default.
- W2000213929 cites W2407196586 @default.
- W2000213929 cites W277578083 @default.
- W2000213929 cites W4235438234 @default.
- W2000213929 doi "https://doi.org/10.1038/sj.onc.1204057" @default.
- W2000213929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11244507" @default.
- W2000213929 hasPublicationYear "2001" @default.
- W2000213929 type Work @default.
- W2000213929 sameAs 2000213929 @default.
- W2000213929 citedByCount "77" @default.
- W2000213929 countsByYear W20002139292012 @default.
- W2000213929 countsByYear W20002139292013 @default.
- W2000213929 countsByYear W20002139292014 @default.
- W2000213929 countsByYear W20002139292015 @default.
- W2000213929 countsByYear W20002139292016 @default.
- W2000213929 countsByYear W20002139292017 @default.
- W2000213929 countsByYear W20002139292018 @default.
- W2000213929 countsByYear W20002139292019 @default.
- W2000213929 countsByYear W20002139292020 @default.
- W2000213929 countsByYear W20002139292021 @default.
- W2000213929 countsByYear W20002139292023 @default.
- W2000213929 crossrefType "journal-article" @default.
- W2000213929 hasAuthorship W2000213929A5027118202 @default.
- W2000213929 hasAuthorship W2000213929A5042588749 @default.
- W2000213929 hasAuthorship W2000213929A5050827716 @default.
- W2000213929 hasAuthorship W2000213929A5067804516 @default.
- W2000213929 hasAuthorship W2000213929A5074188255 @default.
- W2000213929 hasAuthorship W2000213929A5084289729 @default.
- W2000213929 hasAuthorship W2000213929A5085709435 @default.
- W2000213929 hasAuthorship W2000213929A5087133884 @default.
- W2000213929 hasAuthorship W2000213929A5088372604 @default.
- W2000213929 hasBestOaLocation W20002139291 @default.
- W2000213929 hasConcept C104317684 @default.
- W2000213929 hasConcept C111001777 @default.
- W2000213929 hasConcept C143065580 @default.
- W2000213929 hasConcept C170493617 @default.
- W2000213929 hasConcept C2778461978 @default.
- W2000213929 hasConcept C2781080636 @default.
- W2000213929 hasConcept C501734568 @default.
- W2000213929 hasConcept C502942594 @default.
- W2000213929 hasConcept C54355233 @default.
- W2000213929 hasConcept C62478195 @default.
- W2000213929 hasConcept C86803240 @default.
- W2000213929 hasConcept C95444343 @default.
- W2000213929 hasConceptScore W2000213929C104317684 @default.
- W2000213929 hasConceptScore W2000213929C111001777 @default.
- W2000213929 hasConceptScore W2000213929C143065580 @default.
- W2000213929 hasConceptScore W2000213929C170493617 @default.
- W2000213929 hasConceptScore W2000213929C2778461978 @default.
- W2000213929 hasConceptScore W2000213929C2781080636 @default.
- W2000213929 hasConceptScore W2000213929C501734568 @default.
- W2000213929 hasConceptScore W2000213929C502942594 @default.
- W2000213929 hasConceptScore W2000213929C54355233 @default.
- W2000213929 hasConceptScore W2000213929C62478195 @default.
- W2000213929 hasConceptScore W2000213929C86803240 @default.