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- W2000216042 abstract "A case of amphicrine medullary carcinoma of the thyroid is presented. The patient was an 18-year-old female with nonhereditary MEN lib, submucosal neuromas in the oral cavity, and a thyroid tumor that metastasized to regional lymph nodes. Histologically the thyroid tumor was composed of polygonal cells arranged in a solid/trabecular pattern admixed with mucus-producing goblet cells and displaying focal cytoplasmic lumen formation. Immunohistochemical stains were positive for calcitonin, carcinoembryonic antigen, and chromogranin. Electron microscopy demonstrated C-cells containing neurosecretory granules as well as intestinal-type microlumina. The presence of goblet cells and intestinal-type microlumina in medullary carcinoma of the thyroid is reminiscent of amphicrine tumors of the gastrointestinal tract and supports the hypothesis that the parafollicular C-cells of the thyroid may be of endodermal derivation." @default.
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- W2000216042 date "1997-01-01" @default.
- W2000216042 modified "2023-10-18" @default.
- W2000216042 title "Amphicrine Medullary Carcinoma of the Thyroid with Luminal Differentiation: Report of an Immunohistochemical and Ultrastructural Study" @default.
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- W2000216042 doi "https://doi.org/10.3109/01913129709016373" @default.
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