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- W2000217815 abstract "Galectin-3 is a member of the galectin family, which consists of animal lectins that bind β-galactosides. Recently, a role for galectin-3 in the pathophysiology of heart failure has been suggested. It was observed that galectin-3 is specifically upregulated in decompensated heart failure compared with compensated heart failure in animal models of heart failure. This has been associated with activation of fibroblasts and macrophages, which are a hallmark of cardiac remodeling. Therefore, galectin-3 may be a culprit biomarker in heart failure. Initial clinical observations indicate that galectin-3 may be a useful biomarker for decompensated heart failure, with incremental value over well-used “pressure-dependent” biomarkers, such as B-type natriuretic peptide. Future studies should focus on galectin-3 biology to better address the usefulness of galectin-3 as a biomarker and probe the usefulness of anti-galectin-3 therapy in treating heart failure." @default.
- W2000217815 created "2016-06-24" @default.
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- W2000217815 date "2010-02-17" @default.
- W2000217815 modified "2023-10-06" @default.
- W2000217815 title "Galectin-3 in Cardiac Remodeling and Heart Failure" @default.
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- W2000217815 doi "https://doi.org/10.1007/s11897-010-0004-x" @default.
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