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• W2000218210 startingPage "734" @default.
• W2000218210 abstract "In an earlier review of our understanding of the mechanism of nucleotide excision repair (NER) we examined the process with respect to how it occurs in chromatin [1]. We described how much of our mechanistic understanding of NER was derived from biochemical studies that analysed the repair reaction in DNA substrates not representative of that which exists in the living cell. We pointed out that our efforts to understand how NER operates in chromatin had been hampered in part because of the well-known inhibition of NER that occurs when DNA is assembled into nucleosomes and used as the substrate to examine the repair reaction in vitro. Despite this technical bottleneck, we summarized the biochemical, genetic and cell-based studies which have provided insights into the molecular mechanism of NER in the cellular context. More recently, we revisited the topic of how UV induced DNA damage is repaired in chromatin. In this review we examined the commonly held view that depicts a struggle in which the DNA repair machinery battles to overcome the inhibitory effect of chromatin during the repair process. We suggested that in this interpretation of events, the DNA repair mechanisms might be described as ‘tilting at windmills’: fighting an imaginary foe [2]. We surmised that this scenario was overly simplistic, and we described an emerging picture in which the DNA repair process and chromatin remodeling were mechanistically linked and were in fact functioning cooperatively to organize the efficient removal of DNA damage from the genome. Here we discuss the latest findings, which contribute to the idea that DNA damage induced changes to chromatin represent an important way in which the DNA repair process is initiated and organized throughout the genome to promote the efficient removal of damage in response to UV radiation." @default.
• W2000218210 created "2016-06-24" @default.
• W2000218210 creator A5083595167 @default.
• W2000218210 date "2011-07-01" @default.
• W2000218210 modified "2023-10-14" @default.
• W2000218210 title "Nucleotide excision repair in chromatin: Damage removal at the drop of a HAT" @default.
• W2000218210 cites W1480703691 @default.
• W2000218210 cites W1483048309 @default.
• W2000218210 cites W1520588455 @default.
• W2000218210 cites W1534016572 @default.
• W2000218210 cites W1569256715 @default.
• W2000218210 cites W1964922169 @default.
• W2000218210 cites W1967490276 @default.
• W2000218210 cites W1968516742 @default.
• W2000218210 cites W1969270834 @default.
• W2000218210 cites W1971246275 @default.
• W2000218210 cites W1974795717 @default.
• W2000218210 cites W1976833816 @default.
• W2000218210 cites W1976945603 @default.
• W2000218210 cites W1977739594 @default.
• W2000218210 cites W1978793429 @default.
• W2000218210 cites W1979123830 @default.
• W2000218210 cites W1980147942 @default.
• W2000218210 cites W1980887180 @default.
• W2000218210 cites W1981010319 @default.
• W2000218210 cites W1983604067 @default.
• W2000218210 cites W1984762771 @default.
• W2000218210 cites W1985775217 @default.
• W2000218210 cites W1988853516 @default.
• W2000218210 cites W1990287851 @default.
• W2000218210 cites W1990586926 @default.
• W2000218210 cites W1991284791 @default.
• W2000218210 cites W1992082799 @default.
• W2000218210 cites W1999440327 @default.
• W2000218210 cites W2003645332 @default.
• W2000218210 cites W2003843690 @default.
• W2000218210 cites W2013092025 @default.
• W2000218210 cites W2014339767 @default.
• W2000218210 cites W2014766736 @default.
• W2000218210 cites W2015725762 @default.
• W2000218210 cites W2021606478 @default.
• W2000218210 cites W2022561772 @default.
• W2000218210 cites W2023594830 @default.
• W2000218210 cites W2025147350 @default.
• W2000218210 cites W2026368142 @default.
• W2000218210 cites W2026895762 @default.
• W2000218210 cites W2027854680 @default.
• W2000218210 cites W2032739040 @default.
• W2000218210 cites W2034269086 @default.
• W2000218210 cites W2035107826 @default.
• W2000218210 cites W2036997692 @default.
• W2000218210 cites W2038038813 @default.
• W2000218210 cites W2038840504 @default.
• W2000218210 cites W2039057244 @default.
• W2000218210 cites W2039471307 @default.
• W2000218210 cites W2039502138 @default.
• W2000218210 cites W2039876512 @default.
• W2000218210 cites W2044721366 @default.
• W2000218210 cites W2045627002 @default.
• W2000218210 cites W2045868105 @default.
• W2000218210 cites W2046082575 @default.
• W2000218210 cites W2046195682 @default.
• W2000218210 cites W2048066082 @default.
• W2000218210 cites W2048960972 @default.
• W2000218210 cites W2049234029 @default.
• W2000218210 cites W2051031816 @default.
• W2000218210 cites W2052872443 @default.
• W2000218210 cites W2054439862 @default.
• W2000218210 cites W2059299769 @default.
• W2000218210 cites W2060899717 @default.
• W2000218210 cites W2063260609 @default.
• W2000218210 cites W2070933029 @default.
• W2000218210 cites W2071939056 @default.
• W2000218210 cites W2072839034 @default.
• W2000218210 cites W2074155742 @default.
• W2000218210 cites W2074400451 @default.
• W2000218210 cites W2076684722 @default.
• W2000218210 cites W2077479630 @default.
• W2000218210 cites W2080748579 @default.
• W2000218210 cites W2082238239 @default.
• W2000218210 cites W2084908485 @default.
• W2000218210 cites W2088189164 @default.
• W2000218210 cites W2091917798 @default.
• W2000218210 cites W2091931159 @default.
• W2000218210 cites W2096136751 @default.
• W2000218210 cites W2096580557 @default.
• W2000218210 cites W2097183131 @default.
• W2000218210 cites W2097309081 @default.
• W2000218210 cites W2101472561 @default.
• W2000218210 cites W2107981920 @default.
• W2000218210 cites W2109493296 @default.
• W2000218210 cites W2111516090 @default.
• W2000218210 cites W2111736994 @default.
• W2000218210 cites W2112066280 @default.
• W2000218210 cites W2112090753 @default.
• W2000218210 cites W2112652171 @default.
• W2000218210 cites W2116719682 @default.
• W2000218210 cites W2117692326 @default.

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