Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000218505> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2000218505 abstract "Optical microsphere resonators can function as highly sensitive bio/chemical sensors due to the large Q-factor, which leads to high light-matter interaction. The whispering gallery modes (WGM) arise at the surface of the microsphere, creating a highly enhanced optical field that interacts with matter on or near the microsphere surface. As a result, the spectral position of the WGM is extremely sensitive to refractive index changes near the surface, such as when bio/chemical molecules bind to the sphere. We show the potential feasibility of a microsphere ring resonator as a sensor for small molecules by demonstrating detection of sub-femtomole changes in SiO2 molecules at the surface of the microsphere. In this experiment, the silica molecules act as an excellent model for small molecule analytes because of their 60 Dalton molecular weight, and because we know nearly the exact quantity of molecules at the surface, which enables a sensitivity characterization. We measure the spectral shifts in the WGMs when low concentrations of hydrofluoric acid (HF) are added to a solution that is being probed by the microsphere. As the HF molecules break apart the SiO2 molecules at the sphere surface, the WGMs shift due to the sub-nano-scale decrease in the size of the microsphere. These calculations show that the sensitivity of this microsphere resonator is on the order of 500 attomoles. Our results will lead to the utilization of optical microspheres for detection of trace quantities of small molecules for such applications as drug discovery, environmental monitoring, and enzyme detection using peptide cleavage." @default.
- W2000218505 created "2016-06-24" @default.
- W2000218505 creator A5021441966 @default.
- W2000218505 creator A5077974221 @default.
- W2000218505 creator A5084476868 @default.
- W2000218505 date "2006-02-09" @default.
- W2000218505 modified "2023-09-23" @default.
- W2000218505 title "Demonstration of sub-femtomole sensitivity for small molecules with microsphere ring resonator sensors" @default.
- W2000218505 cites W1233592146 @default.
- W2000218505 cites W1978044783 @default.
- W2000218505 cites W1988633531 @default.
- W2000218505 cites W2015665105 @default.
- W2000218505 cites W2020371396 @default.
- W2000218505 cites W2021357995 @default.
- W2000218505 cites W2026269540 @default.
- W2000218505 cites W2039034168 @default.
- W2000218505 cites W2046142803 @default.
- W2000218505 cites W2053691096 @default.
- W2000218505 cites W2057890768 @default.
- W2000218505 cites W2088699934 @default.
- W2000218505 cites W2090863707 @default.
- W2000218505 cites W2120686074 @default.
- W2000218505 cites W2143265323 @default.
- W2000218505 cites W2162661038 @default.
- W2000218505 cites W2172213535 @default.
- W2000218505 cites W2316422128 @default.
- W2000218505 cites W3105282902 @default.
- W2000218505 doi "https://doi.org/10.1117/12.644866" @default.
- W2000218505 hasPublicationYear "2006" @default.
- W2000218505 type Work @default.
- W2000218505 sameAs 2000218505 @default.
- W2000218505 citedByCount "0" @default.
- W2000218505 crossrefType "proceedings-article" @default.
- W2000218505 hasAuthorship W2000218505A5021441966 @default.
- W2000218505 hasAuthorship W2000218505A5077974221 @default.
- W2000218505 hasAuthorship W2000218505A5084476868 @default.
- W2000218505 hasConcept C113196181 @default.
- W2000218505 hasConcept C120665830 @default.
- W2000218505 hasConcept C121332964 @default.
- W2000218505 hasConcept C127413603 @default.
- W2000218505 hasConcept C170395517 @default.
- W2000218505 hasConcept C171250308 @default.
- W2000218505 hasConcept C178790620 @default.
- W2000218505 hasConcept C185592680 @default.
- W2000218505 hasConcept C189942447 @default.
- W2000218505 hasConcept C192562407 @default.
- W2000218505 hasConcept C32909587 @default.
- W2000218505 hasConcept C42067758 @default.
- W2000218505 hasConcept C42360764 @default.
- W2000218505 hasConcept C43617362 @default.
- W2000218505 hasConcept C49040817 @default.
- W2000218505 hasConcept C77255779 @default.
- W2000218505 hasConcept C97126364 @default.
- W2000218505 hasConceptScore W2000218505C113196181 @default.
- W2000218505 hasConceptScore W2000218505C120665830 @default.
- W2000218505 hasConceptScore W2000218505C121332964 @default.
- W2000218505 hasConceptScore W2000218505C127413603 @default.
- W2000218505 hasConceptScore W2000218505C170395517 @default.
- W2000218505 hasConceptScore W2000218505C171250308 @default.
- W2000218505 hasConceptScore W2000218505C178790620 @default.
- W2000218505 hasConceptScore W2000218505C185592680 @default.
- W2000218505 hasConceptScore W2000218505C189942447 @default.
- W2000218505 hasConceptScore W2000218505C192562407 @default.
- W2000218505 hasConceptScore W2000218505C32909587 @default.
- W2000218505 hasConceptScore W2000218505C42067758 @default.
- W2000218505 hasConceptScore W2000218505C42360764 @default.
- W2000218505 hasConceptScore W2000218505C43617362 @default.
- W2000218505 hasConceptScore W2000218505C49040817 @default.
- W2000218505 hasConceptScore W2000218505C77255779 @default.
- W2000218505 hasConceptScore W2000218505C97126364 @default.
- W2000218505 hasLocation W20002185051 @default.
- W2000218505 hasOpenAccess W2000218505 @default.
- W2000218505 hasPrimaryLocation W20002185051 @default.
- W2000218505 hasRelatedWork W1533778991 @default.
- W2000218505 hasRelatedWork W1983168721 @default.
- W2000218505 hasRelatedWork W2158011154 @default.
- W2000218505 hasRelatedWork W2367856617 @default.
- W2000218505 hasRelatedWork W2530329383 @default.
- W2000218505 hasRelatedWork W2759173220 @default.
- W2000218505 hasRelatedWork W2765328031 @default.
- W2000218505 hasRelatedWork W2980835204 @default.
- W2000218505 hasRelatedWork W3132800124 @default.
- W2000218505 hasRelatedWork W2110767176 @default.
- W2000218505 isParatext "false" @default.
- W2000218505 isRetracted "false" @default.
- W2000218505 magId "2000218505" @default.
- W2000218505 workType "article" @default.