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- W2000218608 abstract "Mature HIV-1 particles contain conical-shaped capsids that enclose the viral RNA genome and perform essential functions in the virus life cycle. Previous structural analysis of two- and three-dimensional arrays of the capsid protein (CA) hexamer revealed three interfaces. Here, we present a cryoEM study of a tubular assembly of CA and a high-resolution NMR structure of the CA C-terminal domain (CTD) dimer. In the solution dimer structure, the monomers exhibit different relative orientations compared to previous X-ray structures. The solution structure fits well into the EM density map, suggesting that the dimer interface is retained in the assembled CA. We also identified a CTD-CTD interface at the local three-fold axis in the cryoEM map and confirmed its functional importance by mutagenesis. In the tubular assembly, CA intermolecular interfaces vary slightly, accommodating the asymmetry present in tubes. This provides the necessary plasticity to allow for controlled virus capsid dis/assembly." @default.
- W2000218608 created "2016-06-24" @default.
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- W2000218608 date "2009-11-01" @default.
- W2000218608 modified "2023-10-05" @default.
- W2000218608 title "Structural Convergence between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function" @default.
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- W2000218608 doi "https://doi.org/10.1016/j.cell.2009.10.010" @default.
- W2000218608 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2782912" @default.
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