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• W2000219362 abstract "The crystal structure of the F-actin binding domain 2 of severin, the gelsolin homologue from Dictyostelium discoideum, has been determined by multiple isomorphous replacement and refined to 1.75 Å resolution. The structure reveals an α-helix−β-sheet sandwich similar to the domains of gelsolin and villin, and contains two cation-binding sites, as observed in other domain 1 and domain 2 homologues. Comparison of the structures of several gelsolin family domains has identified residues that may mediate F-actin binding in gelsolin domain 2 homologues. To assess the involvement of these residues in F-actin binding, three mutants of human gelsolin domain 2 were assayed for F-actin binding activity and thermodynamic stability. Two of the mutants, RRV168AAA and RLK210AAA, demonstrated a lowered affinity for F-actin, indicating a role for those residues in filament binding. Using both structural and biochemical data, we have constructed a model of the gelsolin domain 1−domain 2−F-actin complex. This model highlights a number of interactions that may serve as positive and negative determinants of filament end- and side-binding." @default.
• W2000219362 created "2016-06-24" @default.
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• W2000219362 date "2000-04-13" @default.
• W2000219362 modified "2023-10-16" @default.
• W2000219362 title "Mapping the Functional Surface of Domain 2 in the Gelsolin Superfamily^," @default.
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• W2000219362 doi "https://doi.org/10.1021/bi992364d" @default.
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