FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000219477> ?p ?o ?g. }

• W2000219477 endingPage "111" @default.
• W2000219477 startingPage "104" @default.
• W2000219477 abstract "Background: Osteopontin (OPN) is a multifunctional 34‐kDa extracellular matrix protein that can influence the inflammatory process. However, the presence of OPN in human sinonasal mucosa and its roles in the inflammatory process of chronic rhinosinusitis (CRS) are not clear. This study investigated the expression of OPN in human sinonasal mucosa, its cytokine‐driven expression regulation, and its effect on cytokine production in sinonasal mucosa. Methods: Surgical samples were investigated by means of quantitative reverse transcriptase polymerase chain reaction for evaluation of OPN messenger RNA (mRNA) expression, and the presence and location of OPN protein expression were analyzed using immunohistochemistry. Furthermore, nasal explant culture was used to investigate the mutual regulatory interactions between interferon (IFN)‐γ, interleukin (IL)‐4, IL‐5, IL‐13, IL‐1β, and tumor necrosis factor (TNF)‐α and OPN in sinonasal mucosa. Results: Osteopontin expression was significantly upregulated in CRS tissues compared with control tissues. There was a further significant increase of OPN expression in patients with nasal polyps (NPs) and asthma. Immunohistochemistry revealed positive staining of OPN in epithelial cells, submucosal glands, infiltrating cells, and extracellular matrix. Osteopontin mRNA was induced by IFN‐γ, IL‐1β, and TNF‐α, but inhibited by IL‐4 and IL‐13. On the contrary, OPN induced IFN‐γ, IL‐4, IL‐5, IL‐13, IL‐1β, and TNF‐α production in sinonasal mucosa. Conclusions: The expression of OPN is upregulated in CRS. The mutual regulatory interactions between OPN and inflammatory cytokines suggest that OPN may play an important role in the pathogenesis of CRS." @default.
• W2000219477 created "2016-06-24" @default.
• W2000219477 creator A5008835571 @default.
• W2000219477 creator A5026586833 @default.
• W2000219477 creator A5028688074 @default.
• W2000219477 creator A5029837476 @default.
• W2000219477 creator A5031197115 @default.
• W2000219477 creator A5044629451 @default.
• W2000219477 creator A5074819053 @default.
• W2000219477 creator A5082086706 @default.
• W2000219477 date "2008-12-23" @default.
• W2000219477 modified "2023-10-16" @default.
• W2000219477 title "Expression of osteopontin in chronic rhinosinusitis with and without nasal polyps" @default.
• W2000219477 cites W1716523897 @default.
• W2000219477 cites W1978712479 @default.
• W2000219477 cites W1981072805 @default.
• W2000219477 cites W1984629258 @default.
• W2000219477 cites W2017904488 @default.
• W2000219477 cites W2029975301 @default.
• W2000219477 cites W2034341130 @default.
• W2000219477 cites W2036867429 @default.
• W2000219477 cites W2046967922 @default.
• W2000219477 cites W2054568222 @default.
• W2000219477 cites W2072782033 @default.
• W2000219477 cites W2090614253 @default.
• W2000219477 cites W2092227613 @default.
• W2000219477 cites W2107277218 @default.
• W2000219477 cites W2116734097 @default.
• W2000219477 cites W2122844960 @default.
• W2000219477 cites W2129761445 @default.
• W2000219477 cites W2143127434 @default.
• W2000219477 cites W2150989762 @default.
• W2000219477 cites W2314937352 @default.
• W2000219477 cites W4229876265 @default.
• W2000219477 doi "https://doi.org/10.1111/j.1398-9995.2008.01829.x" @default.
• W2000219477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19076536" @default.
• W2000219477 hasPublicationYear "2008" @default.
• W2000219477 type Work @default.
• W2000219477 sameAs 2000219477 @default.
• W2000219477 citedByCount "43" @default.
• W2000219477 countsByYear W20002194772012 @default.
• W2000219477 countsByYear W20002194772013 @default.
• W2000219477 countsByYear W20002194772014 @default.
• W2000219477 countsByYear W20002194772015 @default.
• W2000219477 countsByYear W20002194772016 @default.
• W2000219477 countsByYear W20002194772017 @default.
• W2000219477 countsByYear W20002194772018 @default.
• W2000219477 countsByYear W20002194772020 @default.
• W2000219477 countsByYear W20002194772021 @default.
• W2000219477 countsByYear W20002194772022 @default.
• W2000219477 countsByYear W20002194772023 @default.
• W2000219477 crossrefType "journal-article" @default.
• W2000219477 hasAuthorship W2000219477A5008835571 @default.
• W2000219477 hasAuthorship W2000219477A5026586833 @default.
• W2000219477 hasAuthorship W2000219477A5028688074 @default.
• W2000219477 hasAuthorship W2000219477A5029837476 @default.
• W2000219477 hasAuthorship W2000219477A5031197115 @default.
• W2000219477 hasAuthorship W2000219477A5044629451 @default.
• W2000219477 hasAuthorship W2000219477A5074819053 @default.
• W2000219477 hasAuthorship W2000219477A5082086706 @default.
• W2000219477 hasConcept C104317684 @default.
• W2000219477 hasConcept C127561419 @default.
• W2000219477 hasConcept C142724271 @default.
• W2000219477 hasConcept C164027704 @default.
• W2000219477 hasConcept C17991360 @default.
• W2000219477 hasConcept C189165786 @default.
• W2000219477 hasConcept C203014093 @default.
• W2000219477 hasConcept C204232928 @default.
• W2000219477 hasConcept C2776914184 @default.
• W2000219477 hasConcept C2778690821 @default.
• W2000219477 hasConcept C2780804394 @default.
• W2000219477 hasConcept C2780942790 @default.
• W2000219477 hasConcept C2781390199 @default.
• W2000219477 hasConcept C502942594 @default.
• W2000219477 hasConcept C55493867 @default.
• W2000219477 hasConcept C59377437 @default.
• W2000219477 hasConcept C71924100 @default.
• W2000219477 hasConcept C74172505 @default.
• W2000219477 hasConcept C86803240 @default.
• W2000219477 hasConcept C95444343 @default.
• W2000219477 hasConceptScore W2000219477C104317684 @default.
• W2000219477 hasConceptScore W2000219477C127561419 @default.
• W2000219477 hasConceptScore W2000219477C142724271 @default.
• W2000219477 hasConceptScore W2000219477C164027704 @default.
• W2000219477 hasConceptScore W2000219477C17991360 @default.
• W2000219477 hasConceptScore W2000219477C189165786 @default.
• W2000219477 hasConceptScore W2000219477C203014093 @default.
• W2000219477 hasConceptScore W2000219477C204232928 @default.
• W2000219477 hasConceptScore W2000219477C2776914184 @default.
• W2000219477 hasConceptScore W2000219477C2778690821 @default.
• W2000219477 hasConceptScore W2000219477C2780804394 @default.
• W2000219477 hasConceptScore W2000219477C2780942790 @default.
• W2000219477 hasConceptScore W2000219477C2781390199 @default.
• W2000219477 hasConceptScore W2000219477C502942594 @default.
• W2000219477 hasConceptScore W2000219477C55493867 @default.
• W2000219477 hasConceptScore W2000219477C59377437 @default.
• W2000219477 hasConceptScore W2000219477C71924100 @default.
• W2000219477 hasConceptScore W2000219477C74172505 @default.

• next