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- W2000219887 abstract "In the absence of clinical trials evidence, Juvenile-onset Systemic Lupus Erythematosus (JSLE) treatment plans vary.To explore ‘real world’ treatment utilising longitudinal UK JSLE Cohort Study data.Data collected between 07/2009–05/2020 was used to explore the choice/sequence of immunomodulating drugs from diagnosis. Multivariate logistic regression determined how organ-domain involvement (pBILAG-2004) impacted treatment choice.349 patients met inclusion criteria, median follow-up 4-years (IQR:2,6). Mycophenolate mofetil (MMF) was most commonly used for the majority of organ-domains, and significantly associated with renal involvement (OR:1.99, 95% CI:1.65–2.41, pc < 0.01). Analyses assessing the sequence of immunomodulators focused on 197/349 patients (meeting relevant inclusion/exclusion criteria). 10/197 (5%) solely recieved hydroxychloroquine/prednisolone, 62/197 (31%) received a single-immunomodulator, 69/197 (36%) received two, and 36/197 patients (28%) received ≥three immunomodulators. The most common first and second line immunomodulator was MMF. Rituximab was the most common third-line immunomodulator.Most UK JSLE patients required ≥two immunomodulators, with MMF used most commonly." @default.
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- W2000219887 date "2010-11-01" @default.
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- W2000219887 title "P2 SLICC-ACR damage index in childhood SLE" @default.
- W2000219887 doi "https://doi.org/10.1016/s0973-3698(10)60617-6" @default.
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