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- W2000221862 abstract "The dynamic correlates of the second heart sound were studied by right and left heart catheterization in 15 subjects with pure aortic valve stenosis and in 6 subjects who had no cardiac lesion. The duration of left ventricular systole is not, as previously thought, prolonged in aortic stenosis. Left ventricular ejection is prolonged because of late closure of the aortic valve related to the higher level of left ventricular pressure compared to that of aortic pressure (pressure gradient). In addition, there is a delay in the time of occurrence of the aortic incisura in relation to valve closure. The sum of both these delays (aortic valve closure in relation to end of systole; incisura in relation to valve closure) explains the delay of the aortic component of the second heart sound, which occurs either at the time of the pulmonary component or after it (reverse splitting). The changes of the second heart sound were found to be grossly proportional to the magnitude of the pressure gradient across the aortic valve and, therefore, significant in evaluating the severity of the lesion." @default.
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- W2000221862 date "1971-08-01" @default.
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- W2000221862 title "Mechanism of changes in the second heart sound in aortic stenosis" @default.
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- W2000221862 doi "https://doi.org/10.1016/0002-9149(71)90364-x" @default.
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