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• W2000223386 abstract "Purpose: To assess the effect of short-term hypobaric hypoxic exposure on central corneal thickness (CCT) in healthy participants in 2 different age groups. Methods: Seventy eyes in 35 healthy men were investigated. Twenty participants (mean age 22.8 ± 0.6 years) comprised 1 group, and 15 (mean age 32.1 ± 2.8 years) comprised another group. CCT was measured via ultrasound pachymetry initially at local ground level (792 m above sea level), then during short-term hypobaric hypoxic exposure (equivalent to 9144 m altitude), and then again under ground level conditions. The mean of 10 consecutive CCT measurements in each eye under each set of conditions was used in statistical analysis. Results: In the younger group, initial CCT was 561.5 ± 36.1 μm. This increased to 562.3 ± 36.7 μm under hypobaric hypoxic conditions, and after the return to local ground level conditions, CCT decreased to 560.1 ± 34.5 μm. CCT values under hypobaric hypoxic conditions were not significantly different from those measured before or afterward (P > 0.05). In the older group, initial CCT was 566.0 ± 33.7 μm. This increased to 576.9 ± 28.5 μm under hypobaric hypoxic conditions, and after the return to local ground level conditions, CCT decreased to 567.9 ± 33.3 μm. In the older group, CCT values under hypobaric hypoxic conditions were significantly greater than those measured initially (P < 0.001) or afterward (P < 0.01). In both age groups, initial CCT did not differ significantly from final CCT (P > 0.05). Conclusion: Short-term hypobaric hypoxic exposure increased CCT significantly in the older age group, whereas it yielded a nonsignificant minor increase in the younger age group." @default.
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• W2000223386 date "2009-02-01" @default.
• W2000223386 modified "2023-10-14" @default.
• W2000223386 title "Age-Related Differences in Central Corneal Thickness Alterations Caused by Short-Term Hypobaric Hypoxia" @default.
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• W2000223386 doi "https://doi.org/10.1097/ico.0b013e318183a3aa" @default.
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