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• W2000223817 endingPage "1183" @default.
• W2000223817 startingPage "1176" @default.
• W2000223817 abstract "The conformational features of both free and Ca2+-complexed cyclo[Pro-Phe-Phe-Ala-Xaa]2 (with Xaa= Glu(OtBu), Lys(CIZ), Leu, and Ala) in solution have been determined by NMR spectroscopy and extensive distance-geometry calculations. The decapeptides are conformationally homogeneous in solution and show common structural features in their free and complexed forms. The structures of the free form contain only trans peptide bonds and are topologically similar to the structure of gramicidin-S, folded up in two antiparallel extended structures, stabilized by interstrand hydrogen bonds, and closed at both ends by two beta-turns. In contrast, the Ca2+-complexed peptides present two cis peptide bonds and are generally similar to those observed for the metal-complexed forms of antamanide and related analogues, folded into a saddle shape with two beta-turns. The Glu(OtBu)-, Leu-, and Lys(ClZ)-containing peptides examined here maintain the biological activity of the cyclolinopeptide A in their ability to competitively inhibit cholate uptake. The natural antamanide and cyclolinopeptide A are both able to inhibit the uptake of bile salts into hepatocytes. They share the same postulated active sequence Pro-Phe-Phe. Based on our structural results, we conclude that the ability to adopt a global conformation, characterized by a clear amphipathic separation of hydrophobic and hydrophilic surfaces, is an important feature for the functioning of this class of peptides." @default.
• W2000223817 created "2016-06-24" @default.
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• W2000223817 date "2001-03-16" @default.
• W2000223817 modified "2023-10-13" @default.
• W2000223817 title "Structural Consequences of Metal Complexation ofcyclo[Pro-Phe-Phe-Ala-Xaa]2 Decapeptides" @default.
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• W2000223817 doi "https://doi.org/10.1002/1521-3765(20010316)7:6<1176::aid-chem1176>3.0.co;2-w" @default.
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