FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000224259> ?p ?o ?g. }

• W2000224259 endingPage "623" @default.
• W2000224259 startingPage "612" @default.
• W2000224259 abstract "Depression is a major health problem worldwide. Most prescribed anti-depressants, the selective serotonin reuptake inhibitors (SSRI) show limited efficacy and delayed onset of action, partly due to the activation of somatodendritic 5-HT1A-autoreceptors by the excess extracellular serotonin (5-HT) produced by SSRI in the raphe nuclei. Likewise, 5-HT1A receptor (5-HT1AR) gene polymorphisms leading to high 5-HT1A-autoreceptor expression increase depression susceptibility and decrease treatment response. In this study, we report on a new treatment strategy based on the administration of small-interfering RNA (siRNA) to acutely suppress 5-HT1A-autoreceptor-mediated negative feedback mechanisms. We developed a conjugated siRNA (C-1A-siRNA) by covalently binding siRNA targeting 5-HT1A receptor mRNA with the SSRI sertraline in order to concentrate it in serotonin axons, rich in serotonin transporter (SERT) sites. The intracerebroventricular (i.c.v.) infusion of C-1A-siRNA to mice resulted in its selective accumulation in serotonin neurons. This evoked marked anti-depressant-like effects in the forced swim and tail suspension tests, but did not affect anxiety-like behaviors in the elevated plus-maze. In parallel, C-1A-siRNA administration markedly decreased 5-HT1A-autoreceptor expression and suppressed 8-OH-DPAT-induced hypothermia (a pre-synaptic 5-HT1AR effect in mice) without affecting post-synaptic 5-HT1AR expression in hippocampus and prefrontal cortex. Moreover, i.c.v. C-1A-siRNA infusion augmented the increase in extracellular serotonin evoked by fluoxetine in prefrontal cortex to the level seen in 5-HT1AR knockout mice. Interestingly, intranasal C-1A-siRNA administration produced the same effects, thus opening the way to the therapeutic use of C-1A-siRNA. Hence, C-1A-siRNA represents a new approach to treat mood disorders as monotherapy or in combination with SSRI." @default.
• W2000224259 created "2016-06-24" @default.
• W2000224259 creator A5001562111 @default.
• W2000224259 creator A5003935457 @default.
• W2000224259 creator A5023104507 @default.
• W2000224259 creator A5025935959 @default.
• W2000224259 creator A5032849706 @default.
• W2000224259 creator A5033849687 @default.
• W2000224259 creator A5042366398 @default.
• W2000224259 creator A5044873823 @default.
• W2000224259 creator A5053566929 @default.
• W2000224259 creator A5064184266 @default.
• W2000224259 creator A5064429146 @default.
• W2000224259 creator A5067561723 @default.
• W2000224259 creator A5073930171 @default.
• W2000224259 date "2011-08-02" @default.
• W2000224259 modified "2023-10-16" @default.
• W2000224259 title "Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects" @default.
• W2000224259 cites W1677270978 @default.
• W2000224259 cites W1928975456 @default.
• W2000224259 cites W1966347067 @default.
• W2000224259 cites W1987299915 @default.
• W2000224259 cites W1991420226 @default.
• W2000224259 cites W1994702289 @default.
• W2000224259 cites W1998088135 @default.
• W2000224259 cites W1998865641 @default.
• W2000224259 cites W2005133512 @default.
• W2000224259 cites W2013507314 @default.
• W2000224259 cites W2015068634 @default.
• W2000224259 cites W2016983964 @default.
• W2000224259 cites W2017221228 @default.
• W2000224259 cites W2029827106 @default.
• W2000224259 cites W2035632600 @default.
• W2000224259 cites W2047165821 @default.
• W2000224259 cites W2059171399 @default.
• W2000224259 cites W2059564007 @default.
• W2000224259 cites W2061123136 @default.
• W2000224259 cites W2065897200 @default.
• W2000224259 cites W2070693578 @default.
• W2000224259 cites W2070703400 @default.
• W2000224259 cites W2085463202 @default.
• W2000224259 cites W2103975017 @default.
• W2000224259 cites W2106623141 @default.
• W2000224259 cites W2106885532 @default.
• W2000224259 cites W2112334970 @default.
• W2000224259 cites W2114179943 @default.
• W2000224259 cites W2115182798 @default.
• W2000224259 cites W2116424844 @default.
• W2000224259 cites W2118713264 @default.
• W2000224259 cites W2129932149 @default.
• W2000224259 cites W2130297187 @default.
• W2000224259 cites W2135290698 @default.
• W2000224259 cites W2135447632 @default.
• W2000224259 cites W2150215731 @default.
• W2000224259 cites W2151599925 @default.
• W2000224259 cites W2156868152 @default.
• W2000224259 cites W2158770881 @default.
• W2000224259 cites W2159399023 @default.
• W2000224259 cites W2161037740 @default.
• W2000224259 doi "https://doi.org/10.1038/mp.2011.92" @default.
• W2000224259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21808255" @default.
• W2000224259 hasPublicationYear "2011" @default.
• W2000224259 type Work @default.
• W2000224259 sameAs 2000224259 @default.
• W2000224259 citedByCount "102" @default.
• W2000224259 countsByYear W20002242592012 @default.
• W2000224259 countsByYear W20002242592013 @default.
• W2000224259 countsByYear W20002242592014 @default.
• W2000224259 countsByYear W20002242592015 @default.
• W2000224259 countsByYear W20002242592016 @default.
• W2000224259 countsByYear W20002242592017 @default.
• W2000224259 countsByYear W20002242592018 @default.
• W2000224259 countsByYear W20002242592019 @default.
• W2000224259 countsByYear W20002242592020 @default.
• W2000224259 countsByYear W20002242592021 @default.
• W2000224259 countsByYear W20002242592022 @default.
• W2000224259 countsByYear W20002242592023 @default.
• W2000224259 crossrefType "journal-article" @default.
• W2000224259 hasAuthorship W2000224259A5001562111 @default.
• W2000224259 hasAuthorship W2000224259A5003935457 @default.
• W2000224259 hasAuthorship W2000224259A5023104507 @default.
• W2000224259 hasAuthorship W2000224259A5025935959 @default.
• W2000224259 hasAuthorship W2000224259A5032849706 @default.
• W2000224259 hasAuthorship W2000224259A5033849687 @default.
• W2000224259 hasAuthorship W2000224259A5042366398 @default.
• W2000224259 hasAuthorship W2000224259A5044873823 @default.
• W2000224259 hasAuthorship W2000224259A5053566929 @default.
• W2000224259 hasAuthorship W2000224259A5064184266 @default.
• W2000224259 hasAuthorship W2000224259A5064429146 @default.
• W2000224259 hasAuthorship W2000224259A5067561723 @default.
• W2000224259 hasAuthorship W2000224259A5073930171 @default.
• W2000224259 hasBestOaLocation W20002242591 @default.
• W2000224259 hasConcept C126322002 @default.
• W2000224259 hasConcept C134018914 @default.
• W2000224259 hasConcept C15744967 @default.
• W2000224259 hasConcept C169760540 @default.
• W2000224259 hasConcept C169900460 @default.
• W2000224259 hasConcept C170493617 @default.

• next