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- W2000224628 abstract "Female rats of the Long-Evans strain were thyroidectomized when 26 days of age by a combination of surgery and I131. Injection of iodide (5 mg/day, as KI) was started immediately, and its effect on skeletal growth and maturation was compared simultaneously with that achieved by L-thyroxine replacement therapy (0.25 μg/day) during and at the end of 2 months of injection. Growth was measured by increases in body and tibia length, as shown in roentgenograms taken at intervals during the experiment, and by the width and histology of the proximal epiphysial plate of the tibia at autopsy. Increase in body weight gave additional confirmatory evidence. Maturation was evaluated by examination of selected ossification centers shown in the roentgenograms. The terminal skeletal age assigned each rat on this basis was verified by study of dissected bones. Vigorous and identical growth, at a nearly normal rate, was maintained in both treated groups throughout the experimental period, as contrasted with the severe retar..." @default.
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- W2000224628 date "1963-02-01" @default.
- W2000224628 modified "2023-09-27" @default.
- W2000224628 title "Maintenance of Skeletal Growth and Maturation in Thyroidectomized Rats by Injection of Iodide" @default.
- W2000224628 doi "https://doi.org/10.1210/endo-72-2-283" @default.
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