Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000224910> ?p ?o ?g. }
- W2000224910 endingPage "1510" @default.
- W2000224910 startingPage "1503" @default.
- W2000224910 abstract "We investigated the effect of bioflavonoid quercetin on tyrosine phosphorylation and phospholipase D (PLD, EC 3.1.4.4) activation in rabbit peritoneal neutrophils stimulated by Nformylmethionyleucylphenylalanine (fMLP). The quercetin dose-dependently inhibited degranulation and superoxide production in fMLP-stimulated neutrophils. A strong inhibitory effect of quercetin on the tyrosine phosphorylation of several proteins (40, 42, 43, 45, 46 and 75 kDa) was observed when the neutrophils were pretreated with different concentrations of quercetin. Furthermore, quercetin inhibited mitogen activated protein kinase (MAP kinase) and PLD activation induced by fMLP in a dose-dependent manner. The reduction in PLD activity was 30% at 0.1 μM and 70% at 100 μM of quercetin. These results suggest that impairment of neutrophil functions by quercetin may be due, at least in part, to inhibition of tyrosine phosphorylation and PLD activation. biochem pharmacol 53:10:1503–1510, 1997." @default.
- W2000224910 created "2016-06-24" @default.
- W2000224910 creator A5003759763 @default.
- W2000224910 creator A5037282210 @default.
- W2000224910 creator A5049786044 @default.
- W2000224910 date "1997-05-01" @default.
- W2000224910 modified "2023-10-18" @default.
- W2000224910 title "Inhibition of n-formylmethionyl-leucylphenylalanine-stimulated tyrosine phosphorylation and phospholipase d activation by quercetin in rabbit neutrophils" @default.
- W2000224910 cites W1485641996 @default.
- W2000224910 cites W1554506277 @default.
- W2000224910 cites W1564012501 @default.
- W2000224910 cites W1580046657 @default.
- W2000224910 cites W1589012667 @default.
- W2000224910 cites W1596984507 @default.
- W2000224910 cites W1773790949 @default.
- W2000224910 cites W1887924338 @default.
- W2000224910 cites W1977472414 @default.
- W2000224910 cites W1981354055 @default.
- W2000224910 cites W1998662937 @default.
- W2000224910 cites W2010852330 @default.
- W2000224910 cites W2022108749 @default.
- W2000224910 cites W2044703931 @default.
- W2000224910 cites W2047058759 @default.
- W2000224910 cites W2048982899 @default.
- W2000224910 cites W2068565890 @default.
- W2000224910 cites W2083407604 @default.
- W2000224910 cites W2096609115 @default.
- W2000224910 cites W2127012055 @default.
- W2000224910 cites W2233456179 @default.
- W2000224910 cites W2239705930 @default.
- W2000224910 cites W2286744586 @default.
- W2000224910 cites W2307355608 @default.
- W2000224910 cites W2409344614 @default.
- W2000224910 cites W2412815460 @default.
- W2000224910 cites W2472449491 @default.
- W2000224910 cites W93284168 @default.
- W2000224910 doi "https://doi.org/10.1016/s0006-2952(97)00067-1" @default.
- W2000224910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9260878" @default.
- W2000224910 hasPublicationYear "1997" @default.
- W2000224910 type Work @default.
- W2000224910 sameAs 2000224910 @default.
- W2000224910 citedByCount "17" @default.
- W2000224910 countsByYear W20002249102015 @default.
- W2000224910 countsByYear W20002249102020 @default.
- W2000224910 crossrefType "journal-article" @default.
- W2000224910 hasAuthorship W2000224910A5003759763 @default.
- W2000224910 hasAuthorship W2000224910A5037282210 @default.
- W2000224910 hasAuthorship W2000224910A5049786044 @default.
- W2000224910 hasConcept C11960822 @default.
- W2000224910 hasConcept C153911025 @default.
- W2000224910 hasConcept C170493617 @default.
- W2000224910 hasConcept C181199279 @default.
- W2000224910 hasConcept C185592680 @default.
- W2000224910 hasConcept C195794163 @default.
- W2000224910 hasConcept C2776165026 @default.
- W2000224910 hasConcept C2777553839 @default.
- W2000224910 hasConcept C2778004101 @default.
- W2000224910 hasConcept C2778597717 @default.
- W2000224910 hasConcept C2780795997 @default.
- W2000224910 hasConcept C2781263971 @default.
- W2000224910 hasConcept C42362537 @default.
- W2000224910 hasConcept C49802076 @default.
- W2000224910 hasConcept C55493867 @default.
- W2000224910 hasConcept C6182249 @default.
- W2000224910 hasConcept C62478195 @default.
- W2000224910 hasConcept C86803240 @default.
- W2000224910 hasConcept C98274493 @default.
- W2000224910 hasConceptScore W2000224910C11960822 @default.
- W2000224910 hasConceptScore W2000224910C153911025 @default.
- W2000224910 hasConceptScore W2000224910C170493617 @default.
- W2000224910 hasConceptScore W2000224910C181199279 @default.
- W2000224910 hasConceptScore W2000224910C185592680 @default.
- W2000224910 hasConceptScore W2000224910C195794163 @default.
- W2000224910 hasConceptScore W2000224910C2776165026 @default.
- W2000224910 hasConceptScore W2000224910C2777553839 @default.
- W2000224910 hasConceptScore W2000224910C2778004101 @default.
- W2000224910 hasConceptScore W2000224910C2778597717 @default.
- W2000224910 hasConceptScore W2000224910C2780795997 @default.
- W2000224910 hasConceptScore W2000224910C2781263971 @default.
- W2000224910 hasConceptScore W2000224910C42362537 @default.
- W2000224910 hasConceptScore W2000224910C49802076 @default.
- W2000224910 hasConceptScore W2000224910C55493867 @default.
- W2000224910 hasConceptScore W2000224910C6182249 @default.
- W2000224910 hasConceptScore W2000224910C62478195 @default.
- W2000224910 hasConceptScore W2000224910C86803240 @default.
- W2000224910 hasConceptScore W2000224910C98274493 @default.
- W2000224910 hasIssue "10" @default.
- W2000224910 hasLocation W20002249101 @default.
- W2000224910 hasLocation W20002249102 @default.
- W2000224910 hasOpenAccess W2000224910 @default.
- W2000224910 hasPrimaryLocation W20002249101 @default.
- W2000224910 hasRelatedWork W1566606277 @default.
- W2000224910 hasRelatedWork W1966248035 @default.
- W2000224910 hasRelatedWork W1988628626 @default.
- W2000224910 hasRelatedWork W1999869819 @default.
- W2000224910 hasRelatedWork W2000224910 @default.
- W2000224910 hasRelatedWork W2055675186 @default.
- W2000224910 hasRelatedWork W2057519025 @default.