FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000225569> ?p ?o ?g. }

• W2000225569 endingPage "142" @default.
• W2000225569 startingPage "137" @default.
• W2000225569 abstract "CPI-17 (C-kinase-activated protein phosphatase-1 (PP1) inhibitor, 17kDa) is a cytoplasmic protein predominantly expressed in mature smooth muscle (SM) that regulates the myosin-associated PP1 holoenzyme (MLCP). Here, we show CPI-17 expression in proliferating cells, such as pancreatic cancer and hyperplastic SM cells. Immunofluorescence showed that CPI-17 was concentrated in nuclei of human pancreatic cancer (Panc1) cells. Nuclear accumulation of CPI-17 was also detected in the proliferating vascular SM cell culture and cells at neointima of rat vascular injury model. The N-terminal 21-residue tail domain of CPI-17 was necessary for the nuclear localization. Phospho-mimetic Asp-substitution of CPI-17 at Ser12 attenuated the nuclear import. CPI-17 phosphorylated at Ser12 was not localized at nuclei, suggesting a suppressive role of Ser12 phosphorylation in the nuclear import. Activated CPI-17 bound to all three isoforms of PP1 catalytic subunit in Panc1 nuclear extracts. CPI-17 knockdown in Panc1 resulted in dephosphorylation of histone H3 at Thr3, Ser10 and Thr11, whereas it had no effects on the phosphorylation of myosin light chain and merlin, the known targets of MLCP. In parallel, CPI-17 knockdown suppressed Panc1 proliferation. We propose that CPI-17 accumulated in the nucleus through the N-terminal tail targets multiple PP1 signaling pathways regulating cell proliferation." @default.
• W2000225569 created "2016-06-24" @default.
• W2000225569 creator A5019794037 @default.
• W2000225569 creator A5021985958 @default.
• W2000225569 creator A5030182387 @default.
• W2000225569 creator A5080885107 @default.
• W2000225569 creator A5082081619 @default.
• W2000225569 date "2013-04-01" @default.
• W2000225569 modified "2023-10-16" @default.
• W2000225569 title "Nuclear localization of CPI-17, a protein phosphatase-1 inhibitor protein, affects histone H3 phosphorylation and corresponds to proliferation of cancer and smooth muscle cells" @default.
• W2000225569 cites W1532195966 @default.
• W2000225569 cites W1966046354 @default.
• W2000225569 cites W1974933319 @default.
• W2000225569 cites W1994734279 @default.
• W2000225569 cites W1994790769 @default.
• W2000225569 cites W1996286498 @default.
• W2000225569 cites W2005971493 @default.
• W2000225569 cites W2007194576 @default.
• W2000225569 cites W2014234136 @default.
• W2000225569 cites W2036057310 @default.
• W2000225569 cites W2063576205 @default.
• W2000225569 cites W2066715566 @default.
• W2000225569 cites W2073944180 @default.
• W2000225569 cites W2080964959 @default.
• W2000225569 cites W2087235999 @default.
• W2000225569 cites W2093061813 @default.
• W2000225569 cites W2114901141 @default.
• W2000225569 cites W2120553816 @default.
• W2000225569 cites W2121571633 @default.
• W2000225569 cites W2123721271 @default.
• W2000225569 cites W2126155528 @default.
• W2000225569 cites W2131681216 @default.
• W2000225569 cites W2145953966 @default.
• W2000225569 cites W4244174674 @default.
• W2000225569 doi "https://doi.org/10.1016/j.bbrc.2013.03.055" @default.
• W2000225569 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3644852" @default.
• W2000225569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23541585" @default.
• W2000225569 hasPublicationYear "2013" @default.
• W2000225569 type Work @default.
• W2000225569 sameAs 2000225569 @default.
• W2000225569 citedByCount "17" @default.
• W2000225569 countsByYear W20002255692016 @default.
• W2000225569 countsByYear W20002255692017 @default.
• W2000225569 countsByYear W20002255692018 @default.
• W2000225569 countsByYear W20002255692020 @default.
• W2000225569 countsByYear W20002255692021 @default.
• W2000225569 countsByYear W20002255692022 @default.
• W2000225569 countsByYear W20002255692023 @default.
• W2000225569 crossrefType "journal-article" @default.
• W2000225569 hasAuthorship W2000225569A5019794037 @default.
• W2000225569 hasAuthorship W2000225569A5021985958 @default.
• W2000225569 hasAuthorship W2000225569A5030182387 @default.
• W2000225569 hasAuthorship W2000225569A5080885107 @default.
• W2000225569 hasAuthorship W2000225569A5082081619 @default.
• W2000225569 hasBestOaLocation W20002255692 @default.
• W2000225569 hasConcept C104317684 @default.
• W2000225569 hasConcept C11960822 @default.
• W2000225569 hasConcept C153911025 @default.
• W2000225569 hasConcept C178666793 @default.
• W2000225569 hasConcept C181912034 @default.
• W2000225569 hasConcept C190062978 @default.
• W2000225569 hasConcept C2776745794 @default.
• W2000225569 hasConcept C29512474 @default.
• W2000225569 hasConcept C49805395 @default.
• W2000225569 hasConcept C55493867 @default.
• W2000225569 hasConcept C62112901 @default.
• W2000225569 hasConcept C64927066 @default.
• W2000225569 hasConcept C6997183 @default.
• W2000225569 hasConcept C86339819 @default.
• W2000225569 hasConcept C86803240 @default.
• W2000225569 hasConcept C95444343 @default.
• W2000225569 hasConceptScore W2000225569C104317684 @default.
• W2000225569 hasConceptScore W2000225569C11960822 @default.
• W2000225569 hasConceptScore W2000225569C153911025 @default.
• W2000225569 hasConceptScore W2000225569C178666793 @default.
• W2000225569 hasConceptScore W2000225569C181912034 @default.
• W2000225569 hasConceptScore W2000225569C190062978 @default.
• W2000225569 hasConceptScore W2000225569C2776745794 @default.
• W2000225569 hasConceptScore W2000225569C29512474 @default.
• W2000225569 hasConceptScore W2000225569C49805395 @default.
• W2000225569 hasConceptScore W2000225569C55493867 @default.
• W2000225569 hasConceptScore W2000225569C62112901 @default.
• W2000225569 hasConceptScore W2000225569C64927066 @default.
• W2000225569 hasConceptScore W2000225569C6997183 @default.
• W2000225569 hasConceptScore W2000225569C86339819 @default.
• W2000225569 hasConceptScore W2000225569C86803240 @default.
• W2000225569 hasConceptScore W2000225569C95444343 @default.
• W2000225569 hasIssue "1" @default.
• W2000225569 hasLocation W20002255691 @default.
• W2000225569 hasLocation W20002255692 @default.
• W2000225569 hasLocation W20002255693 @default.
• W2000225569 hasLocation W20002255694 @default.
• W2000225569 hasLocation W20002255695 @default.
• W2000225569 hasOpenAccess W2000225569 @default.
• W2000225569 hasPrimaryLocation W20002255691 @default.
• W2000225569 hasRelatedWork W1660072147 @default.
• W2000225569 hasRelatedWork W1985502400 @default.
• W2000225569 hasRelatedWork W2012302802 @default.

• next