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- W2000225921 abstract "The aim of this study was to detect the association between the microRNA-10b (miR-10b) expression level and prognosis in glioma patients. Quantitative real-time polymerase chain reaction (qRT-PCR) analysis was used to measure the expression of miR-10b levels in different-grade glioma tissues and normal brain tissues. The relationship between miR-10b expression levels and clinical pathological characteristics was statistically analyzed. The influence of miR-10b on survival of glioma patients was also analyzed. As a result, miR-10b expression levels in glioma tissues were significantly increased compared to those of normal brain tissues (p < 0.001). And the increased expression levels were associated with the advanced glioma grade (p < 0.001) and larger tumor size (p < 0.001). Moreover, the results of the Kaplan–Meier survival curve indicated that overall survival (OS) and progression-free survival (PFS) were significantly poorer in the high-expression-level group than those in the low-expression-level group (p < 0.001). Finally, the results of the multivariate Cox regression model indicated that the miR-10b expression level was an independent prognostic factor for glioma patients. Taken together, these findings offer convincing evidence that increased miR-10b expression may be an independent marker to predict poor prognosis in patients with gliomas." @default.
- W2000225921 created "2016-06-24" @default.
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- W2000225921 date "2015-03-14" @default.
- W2000225921 modified "2023-10-18" @default.
- W2000225921 title "Correlation of microRNA-10b upregulation and poor prognosis in human gliomas" @default.
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- W2000225921 doi "https://doi.org/10.1007/s13277-015-3310-9" @default.
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