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- W2000227002 abstract "Colchicine has previously been shown to inhibit the incorporation of [3H]-inositol into phosphatidylinositol in lymphocytes stimulated with concanavalin A. In the present study other agents known to interact with tubulin or affect microtubule assembly/disassembly were examined for effects on 32PO4 incorporation into phospholipids and [3H]inositol incorporation into phosphatidylinositol. Vinblastine inhibited the enhanced incorporation caused by concanavalin A of either [3H]inositol or 32PO4 into phosphatidylinositol and phosphatidic acid. It had no effect on basal incorporation of 32PO4 and enhanced basal incorporation of [3H]inositol into nonstimulated lymphocytes. Griseofulvin at concentrations up to 10(-3) M had no effect on uptake of either label. Deuterium oxide had effects similar to vinblastine in that basal incorporation of both labels was enhanced while inhibition of the concanavalin A stimulated incorporation was observed. These results suggest an action of these various compounds other than or in addition to their known effects on cytoplasmic microtubules." @default.
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- W2000227002 date "1980-09-01" @default.
- W2000227002 modified "2023-10-18" @default.
- W2000227002 title "Effects of colchicine, vinblastine, griseofulvin and deuterium oxide upon phospholipid metabolism in concanavalin A-stimulated lymphocytes" @default.
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- W2000227002 doi "https://doi.org/10.1016/0005-2760(80)90104-6" @default.
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