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- W2000227244 abstract "Abstract The replicative structures of pseudorabies virus DNA were examined by electron microscopy during the first round of parental viral DNA replication. Molecules with replicative “eyes” and branches were observed. Eyes, centering mainly between 18 and 24 μm from one of the ends of linear unit-size molecules, were observed indicating that internal initiation of replication occurred preferentially at that site. Y-shaped molecules with branches of varying sizes were also seen. Some of the molecules had relatively short branches, indicating that initiation of replication of linear molecules occurs near or at the end of the molecules as well. Circular and longer than unit-size molecules with eyes or branches were seen, indicating that parental viral DNA molecules that acquire single-stranded ends within the host cells and, consequently, can circularize and form concatemers proceed to replicate. Viral DNA molecules with terminal loops were also observed; the function of these structures in replication remains uncertain." @default.
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- W2000227244 date "1977-06-01" @default.
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- W2000227244 title "Replication of herpesvirus DNA I. Electron microscopic analysis of replicative structures" @default.
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- W2000227244 doi "https://doi.org/10.1016/0042-6822(77)90355-5" @default.
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