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• W2000227392 abstract "Case Studies1 September 1966Hypogammaglobulinemia with Thymoma, Hemolytic Anemia, and Disseminated Infection with CytomegalovirusEDWARD S. MONGAN, M.D., F.A.C.P., WILLIAM A. KERN JR., M.D., ROGER TERRY, M.D.EDWARD S. MONGAN, M.D., F.A.C.P.Search for more papers by this author, WILLIAM A. KERN JR., M.D.Search for more papers by this author, ROGER TERRY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-3-548 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years it has been established that the intact thymus is a significant contributor to the immunological integrity of a number of neonatal animals. The function of the thymus in adults is unclear, but reports of patients with coexisting thymic tumors and hypogammaglobulinemia suggest that the thymus may contribute to immunologic processes in adult life. A male patient with hypogammaglobulinemia, a thymoma, and probable pulmonary infection with cytomegalovirus has previously been reported by us (1). This report concerns a second case in a female patient with a thymoma removed in 1956. Subsequently she developed multiple bacterial infections, and in...References1. JACOXMONGANHANSHAWLEDDY RFESJBJP: Hypogammaglobulinemia with thymoma and probable pulmonary infection with cytomegalovirus. New Eng. J. Med. 271: 1091, 1964. CrossrefMedlineGoogle Scholar2. BARNETTCONDEMILEDDYVAUGHAN EVJJJPJH: Gamma 2, gamma 1A and gamma IM antinuclear factors in human sera. J. Clin. Invest. 43: 1104, 1964. CrossrefMedlineGoogle Scholar3. BECKERMUNOZLAPRESLELEBEAU ELJCLJ: Antigen-antibody reactions in agar. II. Elementary theory and determination of diffusion coefficients of antigen. J. Immun. 67: 501, 1951. MedlineGoogle Scholar4. RUBINSTEIN HM: Quantitative antigen analysis by the Oudin method. J. Immun. 73: 322, 1954. MedlineGoogle Scholar5. MEDEARIS DN: Observations concerning human cytomegalovirus infection and disease. Bull. Hopkins Hosp. 114: 181, 1964. MedlineGoogle Scholar6. MACLEANZAKVARCOGOOD LDSJRLRA: Thymic tumor and acquired agammaglobulinemia: a clinical and experimental study of the immune response. Surgery 40: 1010, 1956. MedlineGoogle Scholar7. MARTINGORDONMCCULLOUGH CMRSNB: Acquired hypogammaglobulinemia in adults: report of a case, with clinical and experimental studies. New Eng. J. Med. 254: 449, 1956. CrossrefMedlineGoogle Scholar8. RAMOS AJ: Diagnostic problems: presentation of case. JAMA 160: 1317, 1956. CrossrefMedlineGoogle Scholar9. LAMBIEBURROWSSOMERS ATBASC: Clinicopathological conference: refractory anemia, agammaglobulinemia and mediastinal tumor. Amer. J. Clin. Path. 27: 444, 1957. CrossrefMedlineGoogle Scholar10. GAFNIMICHAELIHELLER JDH: Idiopathic acquired agammaglobulinemia associated with thymoma. Report of two cases and review of the literature. New Eng. J. Med. 263: 536, 1960. CrossrefMedlineGoogle Scholar11. CHAPIN MA: Benign thymoma, refractory anemia and hypogammaglobulinemia—case report. J. Maine Med. Ass. 56: 83, 1965. MedlineGoogle Scholar12. GEHRMANNENGSTFELD GG: Thymom und Agammaglobulinamie. Deutsch. Med. Wsehr. 90: 1328, 1965. CrossrefGoogle Scholar13. STERN H: Human cytomegalovirus infection. Proc. Roy. Soc. Med. 58: 346, 1965. CrossrefMedlineGoogle Scholar14. HILLROWLANDSRIFKIND RBDTD: Infectious pulmonary disease in patients receiving immunosuppressive therapy for organ transplantation. New Eng. J. Med. 271: 1021, 1964. CrossrefMedlineGoogle Scholar15. SCHNECK SA: Neuropathological features of human organ transplantation. I. Probable cytomegalovirus infection. J. Neuropath. Exp. Neurol. 24: 415, 1965. CrossrefGoogle Scholar16. SCHMIDKIELYHARRISONBAYRDPEASE JRJMEGEDGL: Thymoma associated with pure red-cell agenesis. Cancer 18: 216, 1965. CrossrefMedlineGoogle Scholar17. HAVARDSCOTT CWRB: Thymic tumor and erythroblastic aplasia. Report of three cases and a review of the syndrome. Brit. J. Haemat. 6: 178, 1960. CrossrefMedlineGoogle Scholar18. ROSSFINCHSTREETSTRIEDER JFSCRBJW: The simultaneous occurrence of benign thymoma and refractory anemia. Blood 9: 935, 1954. CrossrefMedlineGoogle Scholar19. BECKEREDDY FPJR: Autoimmune hemolytic anemia with terminal lymphoma and cytomegalic inclusion disease. New York J. Med. 64: 1211, 1964. MedlineGoogle Scholar20. ZUELZERSTULBERGPAGETERUYABROUGH WWCSRHJAJ: The etiology of acquired hemolytic anemia. The Society for Pediatric Research Program and Abstracts, 1965, p. 29. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New YorkFrom the Departments of Medicine and Pathology, The University of Rochester School of Medicine and Dentistry, Rochester, N. Y.This study was supported by grant CRMC 25 from the Arthritis Foundation, New York, N. Y.This study was presented in part at the XI International Congress of Rheumatology, Mar del Plata, Argentina, in December, 1965.Requests for reprints should be addressed to Edward S. Mongan, M.D., Department of Medicine, Strong Memorial Hospital, 260 Crittenden Blvd., Rochester, N. Y. 14620. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHaemophilus influenzae pneumonia and immunodeficiency in association with thymoma–A presentation of Good's SyndromeHaemophilus influenzae pneumonia and immunodeficiency in association with thymoma—A presentation of Good's SyndromeGood's syndrome remains a mystery after 55 years: A systematic review of the scientific evidenceAUTOIMMUNE HAEMOLYTIC ANAEMIA ASSOCIATED WITH A THYMOMA: CASE REPORT AND REVIEW OF THE LITERATUREThymoma and immunodeficiency (Good syndrome): a report of 2 unusual cases and review of the literatureManagement of Autoimmune Hemolytic AnemiasFatal Subacute Cytomegalovirus Encephalitis Associated With Hypogammaglobulinemia and ThymomaInfections in Patients with Immunodeficiency with Thymoma (Good Syndrome)Unusual presentation of mycosis fungoides as pigmented purpura with malignant thymomaCLINICAL OBSERVATIONS ON A CASE OF IMMUNODEFICIENCY AND THYMOMA (GOOD'S SYNDROME) ASSOCIATED WITH CHRONIC MUCOCUTANEOUS CANDIDIASISCytomegalovirus encephalitis associated with thymoma and immunoglobulin deficiencyProgressive multifocal leukoencephalopathy and cryptococcal meningitis with systemic lupus erythematosus and thymomaAplastische Anämie bei ThymomThymoma and Hypogammaglobulinemia (Good’s Syndrome)Thymoma associated with pancytopenia and Hashimoto's thyroiditisThymic Function, Immunologic Deficiency, and AutoimmunityCasesIMMUNOGLOBULINS IN WARM-TYPE AUTOIMMUNE HÆMOLYTIC ANÆMIABenign thymoma and erythroid hypoplasia. Thirteen-year “cure” following thymectomyThymoma, plasma cell myeloma, red cell aplasia and malabsorption syndromeAutoimmune Hemolytic Anemia and Neoplasia of the Reticuloendothelium With a Hypothesis Concerning Etiologic RelationshipsBERNARD PIROFSKY, M.D., F.A.C.P.Immunological Aspects of NeoplasiaLymphatic Leukaemia associated with Dysproteinaemia in Ferrets 1 September 1966Volume 65, Issue 3Page: 548-554KeywordsCytomegalovirus infectionHemolytic anemiaPathogensPulmonary diseasesRenal transplantationRheumatologyRisk managementThymomaThymusUpper respiratory tract infections Issue Published: 1 September 1966 PDF DownloadLoading ..." @default.
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