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• W2000228858 endingPage "278" @default.
• W2000228858 startingPage "245" @default.
• W2000228858 abstract "This review focuses on the role and regulation of mucin glycoproteins (mucins) in airway health and disease. Mucins are highly glycosylated macromolecules (> or =50% carbohydrate, wt/wt). MUC protein backbones are characterized by numerous tandem repeats that contain proline and are high in serine and/or threonine residues, the sites of O-glycosylation. Secretory and membrane-tethered mucins contribute to mucociliary defense, an innate immune defense system that protects the airways against pathogens and environmental toxins. Inflammatory/immune response mediators and the overproduction of mucus characterize chronic airway diseases: asthma, chronic obstructive pulmonary diseases (COPD), or cystic fibrosis (CF). Specific inflammatory/immune response mediators can activate mucin gene regulation and airway remodeling, including goblet cell hyperplasia (GCH). These processes sustain airway mucin overproduction and contribute to airway obstruction by mucus and therefore to the high morbidity and mortality associated with these diseases. Importantly, mucin overproduction and GCH, although linked, are not synonymous and may follow from different signaling and gene regulatory pathways. In section i, structure, expression, and localization of the 18 human MUC genes and MUC gene products having tandem repeat domains and the specificity and application of MUC-specific antibodies that identify mucin gene products in airway tissues, cells, and secretions are overviewed. Mucin overproduction in chronic airway diseases and secretory cell metaplasia in animal model systems are reviewed in section ii and addressed in disease-specific subsections on asthma, COPD, and CF. Information on regulation of mucin genes by inflammatory/immune response mediators is summarized in section iii. In section iv, deficiencies in understanding the functional roles of mucins at the molecular level are identified as areas for further investigations that will impact on airway health and disease. The underlying premise is that understanding the pathways and processes that lead to mucus overproduction in specific airway diseases will allow circumvention or amelioration of these processes." @default.
• W2000228858 created "2016-06-24" @default.
• W2000228858 creator A5050387705 @default.
• W2000228858 creator A5073196705 @default.
• W2000228858 date "2006-01-01" @default.
• W2000228858 modified "2023-10-16" @default.
• W2000228858 title "Respiratory Tract Mucin Genes and Mucin Glycoproteins in Health and Disease" @default.
• W2000228858 cites W147388322 @default.
• W2000228858 cites W1484561729 @default.
• W2000228858 cites W1492833857 @default.
• W2000228858 cites W1496993956 @default.
• W2000228858 cites W1504629032 @default.
• W2000228858 cites W1524914308 @default.
• W2000228858 cites W1529784093 @default.
• W2000228858 cites W1534616656 @default.
• W2000228858 cites W1539749816 @default.
• W2000228858 cites W1541668845 @default.
• W2000228858 cites W1542181196 @default.
• W2000228858 cites W1546825042 @default.
• W2000228858 cites W1547296487 @default.
• W2000228858 cites W1548285478 @default.
• W2000228858 cites W1548863075 @default.
• W2000228858 cites W1559827811 @default.
• W2000228858 cites W1568026330 @default.
• W2000228858 cites W1574323219 @default.
• W2000228858 cites W1594305728 @default.
• W2000228858 cites W1595402802 @default.
• W2000228858 cites W1608190360 @default.
• W2000228858 cites W1617102100 @default.
• W2000228858 cites W1748529861 @default.
• W2000228858 cites W1750011177 @default.
• W2000228858 cites W1760310372 @default.
• W2000228858 cites W1764482514 @default.
• W2000228858 cites W1775439135 @default.
• W2000228858 cites W181415430 @default.
• W2000228858 cites W1820593401 @default.
• W2000228858 cites W1826845578 @default.
• W2000228858 cites W1827620478 @default.
• W2000228858 cites W1845641771 @default.
• W2000228858 cites W1859326720 @default.
• W2000228858 cites W1874417194 @default.
• W2000228858 cites W1889002087 @default.
• W2000228858 cites W1892540398 @default.
• W2000228858 cites W190762137 @default.
• W2000228858 cites W1954352383 @default.
• W2000228858 cites W1964331251 @default.
• W2000228858 cites W1965642419 @default.
• W2000228858 cites W1966864407 @default.
• W2000228858 cites W1966984604 @default.
• W2000228858 cites W1971285541 @default.
• W2000228858 cites W1971325550 @default.
• W2000228858 cites W1971909044 @default.
• W2000228858 cites W1972960722 @default.
• W2000228858 cites W1973955814 @default.
• W2000228858 cites W1974210630 @default.
• W2000228858 cites W1974238529 @default.
• W2000228858 cites W1974405231 @default.
• W2000228858 cites W1974419017 @default.
• W2000228858 cites W1974813327 @default.
• W2000228858 cites W1976238796 @default.
• W2000228858 cites W1976555242 @default.
• W2000228858 cites W1976616302 @default.
• W2000228858 cites W1977230240 @default.
• W2000228858 cites W1981720530 @default.
• W2000228858 cites W1981956842 @default.
• W2000228858 cites W1986401077 @default.
• W2000228858 cites W1987188600 @default.
• W2000228858 cites W1987386449 @default.
• W2000228858 cites W1989393999 @default.
• W2000228858 cites W1989694167 @default.
• W2000228858 cites W1990674750 @default.
• W2000228858 cites W1990995790 @default.
• W2000228858 cites W1991581285 @default.
• W2000228858 cites W1992119277 @default.
• W2000228858 cites W1992333002 @default.
• W2000228858 cites W1993067940 @default.
• W2000228858 cites W1993380004 @default.
• W2000228858 cites W1994353048 @default.
• W2000228858 cites W1994629283 @default.
• W2000228858 cites W1994773880 @default.
• W2000228858 cites W1995636136 @default.
• W2000228858 cites W1999909589 @default.
• W2000228858 cites W2000430823 @default.
• W2000228858 cites W2003742087 @default.
• W2000228858 cites W2004405596 @default.
• W2000228858 cites W2004635533 @default.
• W2000228858 cites W2004801337 @default.
• W2000228858 cites W2005910673 @default.
• W2000228858 cites W2007927210 @default.
• W2000228858 cites W2010473234 @default.
• W2000228858 cites W2010844072 @default.
• W2000228858 cites W2011367803 @default.
• W2000228858 cites W2013014565 @default.
• W2000228858 cites W2013306854 @default.
• W2000228858 cites W2014055037 @default.
• W2000228858 cites W2014136745 @default.
• W2000228858 cites W2014337005 @default.
• W2000228858 cites W2017020122 @default.

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