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• W2000230045 endingPage "31" @default.
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• W2000230045 abstract "Interleukin-1 (IL-1) is implicated in the pathogenesis of various psychiatric diseases. Peripheral administration of IL-1α to neonatal rats induces cognitive and behavioral abnormalities and, therefore, the IL-1α-treated animals might serve as a schizophrenia model. The present study assessed genetic influences on IL-1α-triggered behavioral impairments, using four different strains of neonatal mice, C3H/He, DBA/2, C57BL/6, and ddY. Neonatal treatments with IL-1α differentially altered adult behavioral/cognitive traits in a strain-dependent manner. IL-1α treatment decreased prepulse inhibition in DBA/2 and C57BL/6 mice but not in C3H/He and ddY. The treatment increased locomotor activity and startle responses in DBA/2 mice and, conversely, decreased startle responses in C3H/He mice. Behavioral alterations were most remarkable in DBA/2 mice but undetectable in ddY mice. The magnitudes of IL-1α actions differed between the brain and periphery and were influenced by mouse genetic background. The IL-1-triggered acute signaling, Iκ-B degradation, was significant in the frontal cortex of DBA/2 mice and in the hypothalamus of C3H/He mice. An increase in brain p38 MAP kinase phosphorylation was also most marked in the DBA/2 strain. In contrast, subchronic influences of IL-1α injections failed to illustrate the strain-dependent behavioral alterations. The peripheral effects of IL-1α did not match the strain-dependency of the behavioral alterations, either. Acceleration of tooth eruption and eyelid opening as well as attenuation of weight gain was most marked in C3H/He mice and the induction of serum amyloid protein was the largest in ddY mice. Thus, the peripheral effects of IL-1α in DBA/2 mice were relatively inferior to those in the other strains. The present animal study suggests that, in early postnatal development, circulating IL-1α trigger brain cytokine signaling and produce distinct influences on later neurobehavioral traits, both depending on genetic background." @default.
• W2000230045 created "2016-06-24" @default.
• W2000230045 creator A5011126050 @default.
• W2000230045 creator A5042490238 @default.
• W2000230045 creator A5051358461 @default.
• W2000230045 creator A5061069554 @default.
• W2000230045 date "2006-01-01" @default.
• W2000230045 modified "2023-10-11" @default.
• W2000230045 title "Strain-dependent behavioral alterations induced by peripheral interleukin-1 challenge in neonatal mice" @default.
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• W2000230045 doi "https://doi.org/10.1016/j.bbr.2005.07.007" @default.
• W2000230045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16137777" @default.
• W2000230045 hasPublicationYear "2006" @default.
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