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- W2000230992 abstract "Initially we established that, in human platelets, low concentrations of HDL3 stimulate phosphatidylcholine (PC) hydrolysis and a transient increase in 1,2-diacylglycerol (DAG). In (3H) PC prelabelled platelets, phosphocholine is released into the medium during HDL3 induced PC turnover with a 1.5 to 2 fold increment, indicating that HDL3 stimulated DAG generation in platelets is likely due to phospholipase C (PLC). GTP or GTP-gamma-S augments, and pertussis toxin inhibits HDL3 stimulated DAG production. Treatment of platelet membranes with HDL3 or with proteoliposome containing apo A-I or A-II substantially prevents 41 kDa protein ADP-ribosylation that was induced by pertussis toxin, with apo A-II having an inhibitory potency greater than apo A-I. These data provide strong evidence that the pertussis sensible G protein (Go or Gi) is directly involved in coupling PLC to HDL3 receptor in platelets." @default.
- W2000230992 created "2016-06-24" @default.
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- W2000230992 date "1992-09-01" @default.
- W2000230992 modified "2023-10-18" @default.
- W2000230992 title "Pertussis toxin sensitive G-protein coupling of HDL receptor to phospholipase C in human platelets" @default.
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- W2000230992 doi "https://doi.org/10.1016/0049-3848(92)90016-4" @default.
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