FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000231350> ?p ?o ?g. }

• W2000231350 endingPage "3971" @default.
• W2000231350 startingPage "3963" @default.
• W2000231350 abstract "ABSTRACT β-1,6-Glucan is a fungus-specific cell wall component that is essential for the retention of many cell wall proteins. We recently reported the discovery of a small molecule inhibitor of β-1,6-glucan biosynthesis in yeasts. In the course of our study of its derivatives, we found a unique feature in their antifungal profile. D21-6076, one of these compounds, exhibited potent in vitro and in vivo antifungal activities against Candida glabrata . Interestingly, although it only weakly reduced the growth of Candida albicans in conventional media, it significantly prolonged the survival of mice infected by the pathogen. Biochemical evaluation of D21-6076 indicated that it inhibited β-1,6-glucan synthesis of C. albicans , leading the cell wall proteins, which play a critical role in its virulence, to be released from the cell. Correspondingly, adhesion of C. albicans cells to mammalian cells and their hyphal elongation were strongly reduced by the drug treatment. The results of the experiment using an in vitro model of vaginal candidiasis showed that D21-6076 strongly inhibited the invasion process of C. albicans without a significant reduction in its growth in the medium. These evidences suggested that D21-6076 probably exhibited in vivo efficacy against C. albicans by inhibiting its invasion process." @default.
• W2000231350 created "2016-06-24" @default.
• W2000231350 creator A5010617075 @default.
• W2000231350 creator A5016684181 @default.
• W2000231350 creator A5016728052 @default.
• W2000231350 creator A5019020192 @default.
• W2000231350 creator A5039249073 @default.
• W2000231350 creator A5039981023 @default.
• W2000231350 creator A5047891831 @default.
• W2000231350 date "2009-09-01" @default.
• W2000231350 modified "2023-09-22" @default.
• W2000231350 title "Effect of β-1,6-Glucan Inhibitors on the Invasion Process of <i>Candida albicans</i> : Potential Mechanism of Their In Vivo Efficacy" @default.
• W2000231350 cites W1540938223 @default.
• W2000231350 cites W1895329547 @default.
• W2000231350 cites W1921642159 @default.
• W2000231350 cites W1993062087 @default.
• W2000231350 cites W1994737139 @default.
• W2000231350 cites W1999340863 @default.
• W2000231350 cites W2006888709 @default.
• W2000231350 cites W2019254756 @default.
• W2000231350 cites W2022268926 @default.
• W2000231350 cites W2040556195 @default.
• W2000231350 cites W2051586681 @default.
• W2000231350 cites W2067503599 @default.
• W2000231350 cites W2071482962 @default.
• W2000231350 cites W2075016274 @default.
• W2000231350 cites W2081458104 @default.
• W2000231350 cites W2088806330 @default.
• W2000231350 cites W2099992860 @default.
• W2000231350 cites W2104507335 @default.
• W2000231350 cites W2106311471 @default.
• W2000231350 cites W2106860332 @default.
• W2000231350 cites W2107734856 @default.
• W2000231350 cites W2113880496 @default.
• W2000231350 cites W2122399727 @default.
• W2000231350 cites W2138571992 @default.
• W2000231350 cites W2140008368 @default.
• W2000231350 cites W2141563676 @default.
• W2000231350 cites W2144541214 @default.
• W2000231350 cites W2145577370 @default.
• W2000231350 cites W2146558016 @default.
• W2000231350 cites W2150336680 @default.
• W2000231350 cites W2152663489 @default.
• W2000231350 cites W2153708939 @default.
• W2000231350 cites W2155112592 @default.
• W2000231350 cites W2163812071 @default.
• W2000231350 cites W2169333620 @default.
• W2000231350 cites W2169594819 @default.
• W2000231350 cites W4248514404 @default.
• W2000231350 doi "https://doi.org/10.1128/aac.00435-09" @default.
• W2000231350 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2737848" @default.
• W2000231350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19596881" @default.
• W2000231350 hasPublicationYear "2009" @default.
• W2000231350 type Work @default.
• W2000231350 sameAs 2000231350 @default.
• W2000231350 citedByCount "33" @default.
• W2000231350 countsByYear W20002313502012 @default.
• W2000231350 countsByYear W20002313502013 @default.
• W2000231350 countsByYear W20002313502014 @default.
• W2000231350 countsByYear W20002313502015 @default.
• W2000231350 countsByYear W20002313502016 @default.
• W2000231350 countsByYear W20002313502017 @default.
• W2000231350 countsByYear W20002313502018 @default.
• W2000231350 countsByYear W20002313502019 @default.
• W2000231350 countsByYear W20002313502020 @default.
• W2000231350 countsByYear W20002313502021 @default.
• W2000231350 countsByYear W20002313502022 @default.
• W2000231350 countsByYear W20002313502023 @default.
• W2000231350 crossrefType "journal-article" @default.
• W2000231350 hasAuthorship W2000231350A5010617075 @default.
• W2000231350 hasAuthorship W2000231350A5016684181 @default.
• W2000231350 hasAuthorship W2000231350A5016728052 @default.
• W2000231350 hasAuthorship W2000231350A5019020192 @default.
• W2000231350 hasAuthorship W2000231350A5039249073 @default.
• W2000231350 hasAuthorship W2000231350A5039981023 @default.
• W2000231350 hasAuthorship W2000231350A5047891831 @default.
• W2000231350 hasBestOaLocation W20002313502 @default.
• W2000231350 hasConcept C104317684 @default.
• W2000231350 hasConcept C125235067 @default.
• W2000231350 hasConcept C145081991 @default.
• W2000231350 hasConcept C150903083 @default.
• W2000231350 hasConcept C202751555 @default.
• W2000231350 hasConcept C207001950 @default.
• W2000231350 hasConcept C2776123893 @default.
• W2000231350 hasConcept C2780670043 @default.
• W2000231350 hasConcept C2780917455 @default.
• W2000231350 hasConcept C2991737395 @default.
• W2000231350 hasConcept C55493867 @default.
• W2000231350 hasConcept C60987743 @default.
• W2000231350 hasConcept C86803240 @default.
• W2000231350 hasConcept C89423630 @default.
• W2000231350 hasConceptScore W2000231350C104317684 @default.
• W2000231350 hasConceptScore W2000231350C125235067 @default.
• W2000231350 hasConceptScore W2000231350C145081991 @default.
• W2000231350 hasConceptScore W2000231350C150903083 @default.
• W2000231350 hasConceptScore W2000231350C202751555 @default.
• W2000231350 hasConceptScore W2000231350C207001950 @default.
• W2000231350 hasConceptScore W2000231350C2776123893 @default.

• next