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• W2000232728 abstract "The aim of this study was to determine whether age-associated alterations in the GABAergic input to pyramidal neurons in the hippocampus are due to a dysfunction of GABAergic interneurons, and/or a decrease in their cholinergic control via nicotinic receptors (nAChRs). Electrophysiological recordings were obtained from pyramidal cells in the CA1 area of hippocampal slices from young (3-4 months old) and aged (25-30 months old) Sprague-Dawley rats. Synaptic GABA(A) receptor-mediated inhibitory postsynaptic currents and inhibitory postsynaptic potentials induced by stimulation of the stratum oriens were significantly smaller in aged rats. The frequency (but not amplitude) of spontaneous and miniature GABA inhibitory postsynaptic currents (IPSCs) was reduced in aged rats, suggesting a presynaptic alteration. Tetanic stimulation of cholinergic afferents to release endogenous acetylcholine, or an exogenous application of the nAChR agonist cytisine, increased the frequency of spontaneous IPSCs in young rats; however these effects were not evident in aged rats, indicating that the nicotinic control of GABA release is lowered during aging. None of these age-related alterations were reversed by a chronic treatment with donepezil, a cholinesterase inhibitor. Immunofluorescent labeling of GABA interneurons with somatostatin (SOM), parvalbumin (PV) or calbindin (CB), together with the vesicular acetylcholine transporter VAChT, revealed a selective loss of subpopulations of SOM and CB positive interneurons. This loss was associated with a general decrease in density of the cholinergic network in aged rats. Thus, the lower GABAergic inhibition observed in the aged rat hippocampus is due to a selective loss/dysfunction of subpopulations of GABAergic interneurons, associated with a widespread cholinergic deficit." @default.
• W2000232728 created "2016-06-24" @default.
• W2000232728 creator A5024810467 @default.
• W2000232728 creator A5054174994 @default.
• W2000232728 creator A5070394350 @default.
• W2000232728 creator A5089989719 @default.
• W2000232728 date "2006-09-01" @default.
• W2000232728 modified "2023-10-01" @default.
• W2000232728 title "Age-related alterations of GABAergic input to CA1 Pyramidal neurons and its control by nicotinic acetylcholine receptors in rat hippocampus" @default.
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• W2000232728 cites W1630155501 @default.
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• W2000232728 cites W1833238563 @default.
• W2000232728 cites W1840439775 @default.
• W2000232728 cites W1965655769 @default.
• W2000232728 cites W1966528911 @default.
• W2000232728 cites W1966565364 @default.
• W2000232728 cites W1968774575 @default.
• W2000232728 cites W1969023217 @default.
• W2000232728 cites W1973245614 @default.
• W2000232728 cites W1973998682 @default.
• W2000232728 cites W1974010226 @default.
• W2000232728 cites W1978530682 @default.
• W2000232728 cites W1979686107 @default.
• W2000232728 cites W1992219500 @default.
• W2000232728 cites W1994067502 @default.
• W2000232728 cites W1994839334 @default.
• W2000232728 cites W1996157865 @default.
• W2000232728 cites W1998815060 @default.
• W2000232728 cites W1999304520 @default.
• W2000232728 cites W2004635171 @default.
• W2000232728 cites W2007031766 @default.
• W2000232728 cites W2009167743 @default.
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• W2000232728 cites W2020413582 @default.
• W2000232728 cites W2021139758 @default.
• W2000232728 cites W2022587387 @default.
• W2000232728 cites W2026003522 @default.
• W2000232728 cites W2028604151 @default.
• W2000232728 cites W2029650881 @default.
• W2000232728 cites W2030492864 @default.
• W2000232728 cites W2030806909 @default.
• W2000232728 cites W2032118090 @default.
• W2000232728 cites W2032599170 @default.
• W2000232728 cites W2036983412 @default.
• W2000232728 cites W2040811043 @default.
• W2000232728 cites W2049334534 @default.
• W2000232728 cites W2050455764 @default.
• W2000232728 cites W2053081316 @default.
• W2000232728 cites W2054726866 @default.
• W2000232728 cites W2056615752 @default.
• W2000232728 cites W2057196462 @default.
• W2000232728 cites W2060589548 @default.
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• W2000232728 cites W2075122537 @default.
• W2000232728 cites W2075300430 @default.
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• W2000232728 doi "https://doi.org/10.1016/j.neuroscience.2006.06.040" @default.
• W2000232728 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16890374" @default.
• W2000232728 hasPublicationYear "2006" @default.
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