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- W2000233598 endingPage "340" @default.
- W2000233598 startingPage "340" @default.
- W2000233598 abstract "Histone deacetylases inhibitors (HDACi) have recently emerged as potent antitumor treatment modality. They are currently tested in many phase I, II and III clinical trials as single agents as wells as in combination schemes. They have demonstrated promising antitumor activity and favorable clinical outcome. Histone deacetylases (HDACs) are involved in the process of epigenetic regulation of gene expression. Epigenetic changes are believed to be crucial for the onset and progression of cancer and have recently gained remarkable attention. Since epigenetic regulation of gene expression is a reversible process, targeting histone deacetylases provides a good rationale for anticancer therapy. The acetylation status of histones regulates the organization of chromatin and the access of transcription factors. Moreover, functions of many non-histone proteins are controlled by acetylation. The broad and complicated influences of HDACi on various molecular processes may account for the observed pleiotropic effects. In this review we summarize recent advances in the understanding of biology of HDACs and mechanism of action of their inhibitors." @default.
- W2000233598 created "2016-06-24" @default.
- W2000233598 creator A5002476482 @default.
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- W2000233598 creator A5013533415 @default.
- W2000233598 creator A5031962066 @default.
- W2000233598 creator A5082007741 @default.
- W2000233598 date "2011-01-01" @default.
- W2000233598 modified "2023-10-18" @default.
- W2000233598 title "HDACi - going through the mechanisms" @default.
- W2000233598 cites W1481633630 @default.
- W2000233598 cites W1567485746 @default.
- W2000233598 cites W1568216467 @default.
- W2000233598 cites W1587947784 @default.
- W2000233598 cites W163567197 @default.
- W2000233598 cites W1687968277 @default.
- W2000233598 cites W1835871681 @default.
- W2000233598 cites W1899314386 @default.
- W2000233598 cites W1935102817 @default.
- W2000233598 cites W1960984881 @default.
- W2000233598 cites W1963919702 @default.
- W2000233598 cites W1965262464 @default.
- W2000233598 cites W1966238464 @default.
- W2000233598 cites W1967018540 @default.
- W2000233598 cites W1968356004 @default.
- W2000233598 cites W1969323007 @default.
- W2000233598 cites W1969373767 @default.
- W2000233598 cites W1970073792 @default.
- W2000233598 cites W1970080316 @default.
- W2000233598 cites W1971353320 @default.
- W2000233598 cites W1971557910 @default.
- W2000233598 cites W1972149587 @default.
- W2000233598 cites W1973262157 @default.
- W2000233598 cites W1973899902 @default.
- W2000233598 cites W1974090542 @default.
- W2000233598 cites W1975692560 @default.
- W2000233598 cites W1980131884 @default.
- W2000233598 cites W1981301540 @default.
- W2000233598 cites W1983094204 @default.
- W2000233598 cites W1984152709 @default.
- W2000233598 cites W1984949963 @default.
- W2000233598 cites W1986920308 @default.
- W2000233598 cites W1986938005 @default.
- W2000233598 cites W1987249631 @default.
- W2000233598 cites W1988351397 @default.
- W2000233598 cites W1990801507 @default.
- W2000233598 cites W1991172705 @default.
- W2000233598 cites W1991660464 @default.
- W2000233598 cites W1992027492 @default.
- W2000233598 cites W1995805772 @default.
- W2000233598 cites W2004980848 @default.
- W2000233598 cites W2005745992 @default.
- W2000233598 cites W2005753547 @default.
- W2000233598 cites W2005792629 @default.
- W2000233598 cites W2008446710 @default.
- W2000233598 cites W2010029659 @default.
- W2000233598 cites W2011182719 @default.
- W2000233598 cites W2012253207 @default.
- W2000233598 cites W2013186220 @default.
- W2000233598 cites W2017663565 @default.
- W2000233598 cites W2019465043 @default.
- W2000233598 cites W2020175157 @default.
- W2000233598 cites W2022811243 @default.
- W2000233598 cites W2023283617 @default.
- W2000233598 cites W2024667955 @default.
- W2000233598 cites W2029130907 @default.
- W2000233598 cites W2029644449 @default.
- W2000233598 cites W2030185116 @default.
- W2000233598 cites W2031046263 @default.
- W2000233598 cites W2031671750 @default.
- W2000233598 cites W2032183631 @default.
- W2000233598 cites W2033858594 @default.
- W2000233598 cites W2034420402 @default.
- W2000233598 cites W2037220545 @default.
- W2000233598 cites W2039278049 @default.
- W2000233598 cites W2040560240 @default.
- W2000233598 cites W2043335790 @default.
- W2000233598 cites W2044227899 @default.
- W2000233598 cites W2044784487 @default.
- W2000233598 cites W2048754595 @default.
- W2000233598 cites W2049763628 @default.
- W2000233598 cites W2049793199 @default.
- W2000233598 cites W2050931169 @default.
- W2000233598 cites W2053344100 @default.
- W2000233598 cites W2054240721 @default.
- W2000233598 cites W2055916581 @default.
- W2000233598 cites W2057087535 @default.
- W2000233598 cites W2058582218 @default.
- W2000233598 cites W2058943350 @default.
- W2000233598 cites W2059024085 @default.
- W2000233598 cites W2063528655 @default.
- W2000233598 cites W2063862684 @default.
- W2000233598 cites W2064488799 @default.
- W2000233598 cites W2064971912 @default.
- W2000233598 cites W2069019880 @default.
- W2000233598 cites W2070433411 @default.
- W2000233598 cites W2071831973 @default.