Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000235249> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2000235249 endingPage "135" @default.
- W2000235249 startingPage "130" @default.
- W2000235249 abstract "We have developed and describe a new method of altering B-cell-mediated autoimmune diseases by induction of anti-idiotypic (Id) antibodies (Abs) by immunization with complementary peptides. Specifically, a peptide denoted RhCA 67-16 encoded by RNA complementary to RNA for the Torpedo acetylcholine receptor (AChR) main immunogenic region, AChR 61-76, was tested in the Lewis rat model of experimental autoimmune myasthenia gravis (EAMG). Immunization with RhCA 67-16 induced monoclonal and polyclonal anti-Id Ab against Abs to Torpedo AChR 61-76. RhCA 67-16 antisera inhibited AChR binding by AChR-specific Abs. In addition, a mAb to RhCA 67-16 (denoted TCM 240) recognized two well known EAMG-causing mAbs, 6 and 35. TCM 240, but not a control mAb F28C, inhibited mAb 6 binding to Torpedo AChR 67-76 peptide. mAb 35 binding to TCM 240 was inhibited by native Torpedo AChR as well as by RhCA 67-16. In in vivo experiments, immunization with a RhCA 67-16 keyhole limpet hemacyanin (KLH) conjugate blocked the development of EAMG after challenge with native Torpedo AChR (25% disease incidence versus 90% in the controls). This new approach may provide a novel therapy for MG and perhaps other B-cell-mediated autoimmune disorders through the induction of anti-Id Abs with complementary peptide antigens." @default.
- W2000235249 created "2016-06-24" @default.
- W2000235249 creator A5065607448 @default.
- W2000235249 creator A5085339251 @default.
- W2000235249 date "1994-10-01" @default.
- W2000235249 modified "2023-09-25" @default.
- W2000235249 title "Use of Complementary Peptides and Their Antibodies in B-Cell-Mediated Autoimmune Disease: Prevention of Experimental Autoimmune Myasthenia Gravis with a Peptide Vaccine" @default.
- W2000235249 doi "https://doi.org/10.1006/immu.1994.1047" @default.
- W2000235249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7874437" @default.
- W2000235249 hasPublicationYear "1994" @default.
- W2000235249 type Work @default.
- W2000235249 sameAs 2000235249 @default.
- W2000235249 citedByCount "16" @default.
- W2000235249 countsByYear W20002352492013 @default.
- W2000235249 countsByYear W20002352492015 @default.
- W2000235249 countsByYear W20002352492016 @default.
- W2000235249 countsByYear W20002352492018 @default.
- W2000235249 countsByYear W20002352492020 @default.
- W2000235249 crossrefType "journal-article" @default.
- W2000235249 hasAuthorship W2000235249A5065607448 @default.
- W2000235249 hasAuthorship W2000235249A5085339251 @default.
- W2000235249 hasConcept C123419017 @default.
- W2000235249 hasConcept C147483822 @default.
- W2000235249 hasConcept C153911025 @default.
- W2000235249 hasConcept C159654299 @default.
- W2000235249 hasConcept C170493617 @default.
- W2000235249 hasConcept C185592680 @default.
- W2000235249 hasConcept C203014093 @default.
- W2000235249 hasConcept C2776727803 @default.
- W2000235249 hasConcept C2778105408 @default.
- W2000235249 hasConcept C2778943623 @default.
- W2000235249 hasConcept C2779075594 @default.
- W2000235249 hasConcept C2779281246 @default.
- W2000235249 hasConcept C2780801004 @default.
- W2000235249 hasConcept C542903549 @default.
- W2000235249 hasConcept C55493867 @default.
- W2000235249 hasConcept C74505204 @default.
- W2000235249 hasConcept C80161118 @default.
- W2000235249 hasConcept C86803240 @default.
- W2000235249 hasConcept C956191 @default.
- W2000235249 hasConceptScore W2000235249C123419017 @default.
- W2000235249 hasConceptScore W2000235249C147483822 @default.
- W2000235249 hasConceptScore W2000235249C153911025 @default.
- W2000235249 hasConceptScore W2000235249C159654299 @default.
- W2000235249 hasConceptScore W2000235249C170493617 @default.
- W2000235249 hasConceptScore W2000235249C185592680 @default.
- W2000235249 hasConceptScore W2000235249C203014093 @default.
- W2000235249 hasConceptScore W2000235249C2776727803 @default.
- W2000235249 hasConceptScore W2000235249C2778105408 @default.
- W2000235249 hasConceptScore W2000235249C2778943623 @default.
- W2000235249 hasConceptScore W2000235249C2779075594 @default.
- W2000235249 hasConceptScore W2000235249C2779281246 @default.
- W2000235249 hasConceptScore W2000235249C2780801004 @default.
- W2000235249 hasConceptScore W2000235249C542903549 @default.
- W2000235249 hasConceptScore W2000235249C55493867 @default.
- W2000235249 hasConceptScore W2000235249C74505204 @default.
- W2000235249 hasConceptScore W2000235249C80161118 @default.
- W2000235249 hasConceptScore W2000235249C86803240 @default.
- W2000235249 hasConceptScore W2000235249C956191 @default.
- W2000235249 hasIssue "2" @default.
- W2000235249 hasLocation W20002352491 @default.
- W2000235249 hasLocation W20002352492 @default.
- W2000235249 hasOpenAccess W2000235249 @default.
- W2000235249 hasPrimaryLocation W20002352491 @default.
- W2000235249 hasRelatedWork W183224497 @default.
- W2000235249 hasRelatedWork W1967604970 @default.
- W2000235249 hasRelatedWork W2019181620 @default.
- W2000235249 hasRelatedWork W2028527920 @default.
- W2000235249 hasRelatedWork W2035919986 @default.
- W2000235249 hasRelatedWork W2040541531 @default.
- W2000235249 hasRelatedWork W2083001913 @default.
- W2000235249 hasRelatedWork W2111470622 @default.
- W2000235249 hasRelatedWork W2203716789 @default.
- W2000235249 hasRelatedWork W2489218626 @default.
- W2000235249 hasVolume "5" @default.
- W2000235249 isParatext "false" @default.
- W2000235249 isRetracted "false" @default.
- W2000235249 magId "2000235249" @default.
- W2000235249 workType "article" @default.