Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000235712> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2000235712 endingPage "8" @default.
- W2000235712 startingPage "1" @default.
- W2000235712 abstract "<b><i>Objectives:</i></b> To investigate the effects of allitridin on human ether-à-go-go-related gene (hERG) channels. <b><i>Methods:</i></b> We used whole-cell patch clamping and laser confocal scanning microscopy to evaluate the effects of allitridin on hERG currents and the membrane expression of the hERG protein expressed in HEK 293 cells. <b><i>Results:</i></b> The amplitude of <i>I</i><sub>Kr</sub> showed a concentration-dependent decrease with increasing allitridin concentration. Additionally, alterations in the gating properties of hERG channels were also confirmed. Allitridin does not alter the voltage- and time-dependent activation of hERG channels, the gating properties of hERG channel inactivation over time or the recovery from inactivation, but allitridin does cause alterations in the steady-state inactivation and the deactivation of hERG channels. We further evaluated the influence of allitridin on membrane expression of the hERG protein. Images of allitridin-treated cells showed a reduction in hERG protein on the membrane and retention in the cytoplasm. <b><i>Conclusions:</i></b> To the best of our knowledge this is the first study to show that allitridin reduces the <i>I</i><sub>Kr</sub> current by impairing the trafficking of hERG channels. The results may demonstrate that allitridin could be a promising candidate for the prevention and treatment of arrhythmia-related diseases." @default.
- W2000235712 created "2016-06-24" @default.
- W2000235712 creator A5006788573 @default.
- W2000235712 creator A5036875298 @default.
- W2000235712 creator A5050491353 @default.
- W2000235712 creator A5057908917 @default.
- W2000235712 creator A5063511354 @default.
- W2000235712 creator A5068457627 @default.
- W2000235712 creator A5083848380 @default.
- W2000235712 date "2014-01-01" @default.
- W2000235712 modified "2023-10-10" @default.
- W2000235712 title "Allitridin Reduces <b><i>I</i></b><sub>Kr</sub> Current by Disrupting the Trafficking of Human Ether-à-Go-Go-Related Gene Channels" @default.
- W2000235712 cites W1849483132 @default.
- W2000235712 cites W1928770233 @default.
- W2000235712 cites W1971583785 @default.
- W2000235712 cites W1989483326 @default.
- W2000235712 cites W2004021775 @default.
- W2000235712 cites W2007575887 @default.
- W2000235712 cites W2020599071 @default.
- W2000235712 cites W2026550698 @default.
- W2000235712 cites W2040826404 @default.
- W2000235712 cites W2054064167 @default.
- W2000235712 cites W2057378845 @default.
- W2000235712 cites W2063315937 @default.
- W2000235712 cites W2080380609 @default.
- W2000235712 cites W2085048839 @default.
- W2000235712 cites W2106962270 @default.
- W2000235712 cites W2131308754 @default.
- W2000235712 cites W2133107130 @default.
- W2000235712 cites W2145357374 @default.
- W2000235712 cites W2152259747 @default.
- W2000235712 cites W2161969490 @default.
- W2000235712 cites W2172222575 @default.
- W2000235712 doi "https://doi.org/10.1159/000357232" @default.
- W2000235712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24504171" @default.
- W2000235712 hasPublicationYear "2014" @default.
- W2000235712 type Work @default.
- W2000235712 sameAs 2000235712 @default.
- W2000235712 citedByCount "6" @default.
- W2000235712 countsByYear W20002357122017 @default.
- W2000235712 countsByYear W20002357122018 @default.
- W2000235712 countsByYear W20002357122019 @default.
- W2000235712 countsByYear W20002357122022 @default.
- W2000235712 countsByYear W20002357122023 @default.
- W2000235712 crossrefType "journal-article" @default.
- W2000235712 hasAuthorship W2000235712A5006788573 @default.
- W2000235712 hasAuthorship W2000235712A5036875298 @default.
- W2000235712 hasAuthorship W2000235712A5050491353 @default.
- W2000235712 hasAuthorship W2000235712A5057908917 @default.
- W2000235712 hasAuthorship W2000235712A5063511354 @default.
- W2000235712 hasAuthorship W2000235712A5068457627 @default.
- W2000235712 hasAuthorship W2000235712A5083848380 @default.
- W2000235712 hasConcept C12554922 @default.
- W2000235712 hasConcept C147944092 @default.
- W2000235712 hasConcept C153911025 @default.
- W2000235712 hasConcept C170493617 @default.
- W2000235712 hasConcept C185592680 @default.
- W2000235712 hasConcept C2779362680 @default.
- W2000235712 hasConcept C55493867 @default.
- W2000235712 hasConcept C83743174 @default.
- W2000235712 hasConcept C86803240 @default.
- W2000235712 hasConceptScore W2000235712C12554922 @default.
- W2000235712 hasConceptScore W2000235712C147944092 @default.
- W2000235712 hasConceptScore W2000235712C153911025 @default.
- W2000235712 hasConceptScore W2000235712C170493617 @default.
- W2000235712 hasConceptScore W2000235712C185592680 @default.
- W2000235712 hasConceptScore W2000235712C2779362680 @default.
- W2000235712 hasConceptScore W2000235712C55493867 @default.
- W2000235712 hasConceptScore W2000235712C83743174 @default.
- W2000235712 hasConceptScore W2000235712C86803240 @default.
- W2000235712 hasIssue "1" @default.
- W2000235712 hasLocation W20002357121 @default.
- W2000235712 hasLocation W20002357122 @default.
- W2000235712 hasOpenAccess W2000235712 @default.
- W2000235712 hasPrimaryLocation W20002357121 @default.
- W2000235712 hasRelatedWork W1964429833 @default.
- W2000235712 hasRelatedWork W2004143214 @default.
- W2000235712 hasRelatedWork W2224561562 @default.
- W2000235712 hasRelatedWork W2385176120 @default.
- W2000235712 hasRelatedWork W2385954327 @default.
- W2000235712 hasRelatedWork W2388409414 @default.
- W2000235712 hasRelatedWork W2477223983 @default.
- W2000235712 hasRelatedWork W2584928102 @default.
- W2000235712 hasRelatedWork W2902463392 @default.
- W2000235712 hasRelatedWork W2566712748 @default.
- W2000235712 hasVolume "128" @default.
- W2000235712 isParatext "false" @default.
- W2000235712 isRetracted "false" @default.
- W2000235712 magId "2000235712" @default.
- W2000235712 workType "article" @default.