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- W2000235771 endingPage "e85189" @default.
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- W2000235771 abstract "In both vertebrates and invertebrates, Transient Receptor Potential (TRP) channels are expressed in sensory neurons and mediate environmental stimuli such as light, sound, temperature, and taste. Some of these channels, however, are expressed only in the brain and their functions remain incompletely understood. Using the GAL4/UAS binary system with a line in which the GAL4 had been knocked into the trpA1 locus in Drosophila, we recently reported new insights into TRPA1 localization and function, including its expression in approximately 15% of all circadian neurons. TRPA1 is expressed in lateral posterior neurons (LPNs), which are known to be highly sensitive to entrainment by temperature cycles. Here, I used the bacterial sodium channel, NaChBac, to examine the effects of altering the electrical properties of trpA1 neurons on circadian rhythms. My results indicate that circadian activity of the flies in the morning, daytime, and evening was affected in a temperature-dependent manner following TRPA1 neuronal activation. Remarkably, TRPA1 neuron activation in flies kept at 18°C impacted the morning peak of circadian activity even though TRPA1 is not expressed in morning cells. Taken together, these results suggest that the activation of TRPA1-expressing neurons may differentially coordinate light/dark circadian entrainment, depending on the temperature." @default.
- W2000235771 created "2016-06-24" @default.
- W2000235771 creator A5049799625 @default.
- W2000235771 date "2013-12-18" @default.
- W2000235771 modified "2023-09-23" @default.
- W2000235771 title "Contribution of Drosophila TRPA1-Expressing Neurons to Circadian Locomotor Activity Patterns" @default.
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- W2000235771 doi "https://doi.org/10.1371/journal.pone.0085189" @default.
- W2000235771 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3867552" @default.
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