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- W2000236009 abstract "Studies in autonomic targets have shown that nerves may be required for the development and maintenance of postsynaptic receptor populations. We have examined this relationship in the rat mesenteric artery, assessing mRNA expression levels for a range of neuroreceptors after neonatal sympathectomy, using 6-hydroxydopamine or antisera directed against nerve growth factor, and sensory denervation, using capsaicin. Total RNA was extracted from 28 day old rats and reverse transcription-polymerase chain reaction was performed, using primers specific for the alpha1(A,B,D)- and alpha2(A,B,C)-adrenergic, neurokinin (NKI-NK3), muscarinic (M1-M5) and P2X purinergic (P2x1-7) receptor families. Results showed no decreases in mRNA expression of any of the specific receptor subtypes after either sympathetic or sensory denervation. Small increases in mRNA expression were detected following sensory denervation for some of the receptor subtypes. We conclude that neither sympathetic nor sensory nerves are mandatory for the expression of mRNA of a range of neuroreceptors in the mesenteric vascular bed of the rat." @default.
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- W2000236009 date "1999-07-01" @default.
- W2000236009 modified "2023-09-27" @default.
- W2000236009 title "NEURORECEPTOR mRNA EXPRESSION IN THE RAT MESENTERIC ARTERY DEVELOPS INDEPENDENTLY OF INNERVATION" @default.
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- W2000236009 doi "https://doi.org/10.1016/s0736-5748(99)00032-5" @default.
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