FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000236838> ?p ?o ?g. }

• W2000236838 endingPage "778" @default.
• W2000236838 startingPage "763" @default.
• W2000236838 abstract "We have previously identified two broad electrophysiological classes of spiral ganglion neuron that differ in their rate of accommodation ( Mo & Davis, 1997 a ). In order to understand the underlying ionic basis of these characteristic firing patterns, we used α‐dendrotoxin (α‐DTX) to eliminate the contribution of a class of voltage‐gated K + channels and assessed its effects on a variety of electrophysiological properties by using the whole‐cell configuration of the patch‐clamp technique. Exposure to α‐DTX caused neurons that initially displayed rapid accommodation to fire continuously during 240 ms depolarizing test pulses within a restricted voltage range. We found a non‐monotonic relationship between number of action potentials fired and membrane potential in the presence of α‐DTX that peaked at voltages between –40 to –10 mV and declined at more depolarized and hyperpolarized test potentials. The α‐DTX‐sensitive current had two components that activated in different voltage ranges. Analysis of recordings made from acutely isolated neurons gave estimated half‐maximal activation voltages of –63 and 12 mV for the two components. Because α‐DTX blocks the Kv1.1, Kv1.2 and Kv1.6 subunits, we examined the action of the Kv1.1‐selective blocker dendrotoxin K (DTX‐K). We found that this antagonist reproduced the effects of α‐DTX on neuronal firing, and that the DTX‐K‐sensitive current also had two separate components. These data suggest that the transformation from a rapidly adapting to a slowly adapting firing pattern was mediated by the low voltage‐activated component of DTX‐sensitive current with a potential contribution from the high voltage‐activated component at more depolarized potentials. In addition, the effects of DTX‐K indicate that Kv1.1 subunits are important constituents of the underlying voltage‐gated potassium channels." @default.
• W2000236838 created "2016-06-24" @default.
• W2000236838 creator A5029892937 @default.
• W2000236838 creator A5047557794 @default.
• W2000236838 creator A5049370671 @default.
• W2000236838 date "2002-08-01" @default.
• W2000236838 modified "2023-10-18" @default.
• W2000236838 title "Dendrotoxin‐sensitive K⁺ currents contribute to accommodation in murine spiral ganglion neurons" @default.
• W2000236838 cites W1496404064 @default.
• W2000236838 cites W1555378687 @default.
• W2000236838 cites W1571824892 @default.
• W2000236838 cites W1577757039 @default.
• W2000236838 cites W1583880086 @default.
• W2000236838 cites W1589854409 @default.
• W2000236838 cites W161931647 @default.
• W2000236838 cites W1657691208 @default.
• W2000236838 cites W1665269581 @default.
• W2000236838 cites W175269125 @default.
• W2000236838 cites W1828805485 @default.
• W2000236838 cites W1830560196 @default.
• W2000236838 cites W1893397835 @default.
• W2000236838 cites W1904956466 @default.
• W2000236838 cites W1935182457 @default.
• W2000236838 cites W1966265394 @default.
• W2000236838 cites W1967315405 @default.
• W2000236838 cites W1971428710 @default.
• W2000236838 cites W1972020540 @default.
• W2000236838 cites W1981292655 @default.
• W2000236838 cites W1981911470 @default.
• W2000236838 cites W1989725123 @default.
• W2000236838 cites W1994815743 @default.
• W2000236838 cites W1995154586 @default.
• W2000236838 cites W1997293666 @default.
• W2000236838 cites W1997511216 @default.
• W2000236838 cites W2001193044 @default.
• W2000236838 cites W2003576683 @default.
• W2000236838 cites W2007198002 @default.
• W2000236838 cites W2007783597 @default.
• W2000236838 cites W2009074935 @default.
• W2000236838 cites W2009667219 @default.
• W2000236838 cites W2015426350 @default.
• W2000236838 cites W2020104278 @default.
• W2000236838 cites W2020230900 @default.
• W2000236838 cites W2023718576 @default.
• W2000236838 cites W2028922161 @default.
• W2000236838 cites W2038894306 @default.
• W2000236838 cites W2047354806 @default.
• W2000236838 cites W2047439107 @default.
• W2000236838 cites W2051505932 @default.
• W2000236838 cites W2061805084 @default.
• W2000236838 cites W2065939635 @default.
• W2000236838 cites W2067091061 @default.
• W2000236838 cites W2070568509 @default.
• W2000236838 cites W2072381786 @default.
• W2000236838 cites W2083207133 @default.
• W2000236838 cites W2085764807 @default.
• W2000236838 cites W20878730 @default.
• W2000236838 cites W2088919858 @default.
• W2000236838 cites W2094909624 @default.
• W2000236838 cites W2100619983 @default.
• W2000236838 cites W2106451614 @default.
• W2000236838 cites W2117931565 @default.
• W2000236838 cites W2124278680 @default.
• W2000236838 cites W2126116200 @default.
• W2000236838 cites W2128595626 @default.
• W2000236838 cites W2149706830 @default.
• W2000236838 cites W2155756146 @default.
• W2000236838 cites W2158689185 @default.
• W2000236838 cites W2163491306 @default.
• W2000236838 cites W2170239327 @default.
• W2000236838 cites W2243008810 @default.
• W2000236838 cites W2244332295 @default.
• W2000236838 cites W2339785731 @default.
• W2000236838 cites W2410767593 @default.
• W2000236838 cites W2419477283 @default.
• W2000236838 cites W2431496838 @default.
• W2000236838 cites W2432180276 @default.
• W2000236838 cites W54041965 @default.
• W2000236838 doi "https://doi.org/10.1113/jphysiol.2002.017202" @default.
• W2000236838 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2290456" @default.
• W2000236838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12154177" @default.
• W2000236838 hasPublicationYear "2002" @default.
• W2000236838 type Work @default.
• W2000236838 sameAs 2000236838 @default.
• W2000236838 citedByCount "93" @default.
• W2000236838 countsByYear W20002368382012 @default.
• W2000236838 countsByYear W20002368382013 @default.
• W2000236838 countsByYear W20002368382014 @default.
• W2000236838 countsByYear W20002368382015 @default.
• W2000236838 countsByYear W20002368382016 @default.
• W2000236838 countsByYear W20002368382017 @default.
• W2000236838 countsByYear W20002368382018 @default.
• W2000236838 countsByYear W20002368382019 @default.
• W2000236838 countsByYear W20002368382020 @default.
• W2000236838 countsByYear W20002368382021 @default.
• W2000236838 countsByYear W20002368382022 @default.
• W2000236838 countsByYear W20002368382023 @default.
• W2000236838 crossrefType "journal-article" @default.

• next