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- W2000236991 abstract "Using Parkinson's disease as a prototype of neurodegenerative diseases, we propose applications of human stem cells in the development of therapeutics for neurodegenerative diseases. First, in vitro differentiation of human stem cells offers a versatile model for dissecting molecular interactions underlying human dopamine (DA) neuron specification, which may form a foundation for instigating regeneration of DA neurons from progenitors that reside in the brain. Second, stem cells derived from diseased cells or through genetic modification can serve as a platform for unraveling biochemical processes that lead to the cellular pathogenesis of degeneration. This may in turn serve as a template for identifying or developing therapeutics for slowing, stopping, or reversing the disease process. And finally, stem cells, particularly those induced from patients' own cells, provide a reliable source of DA neurons for cell-based therapy." @default.
- W2000236991 created "2016-06-24" @default.
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- W2000236991 date "2008-12-01" @default.
- W2000236991 modified "2023-10-06" @default.
- W2000236991 title "Stem cells in development of therapeutics for Parkinson's disease: A perspective" @default.
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- W2000236991 doi "https://doi.org/10.1002/jcb.21916" @default.
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