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• W2000237223 abstract "Akt is involved in different cellular processes such as cell growth, cell differentiation, and anti-apoptosis.To investigate the role of Akt in cell growth and survival in PANC-1 pancreatic cancer cells.Insulin-like growth factor (IGF)-I induced Akt activation in a dose-dependent manner and stimulated anchorage-dependent and anchorage-independent cell growth of PANC-1 cells. In PANC-1 cells infected with adenovirus vectors carrying kinase-deficient Akt, anchorage-dependent and anchorage-independent cell growth was significantly reduced in the presence or absence of IGF-I compared with cells infected with adenovirus vectors carrying wild-type Akt, although IGF-I significantly stimulated cell growth in both transfected cell lines. Conversely, in PANC-1 cells infected with adenovirus vectors carrying kinase-deficient Akt, typical DNA laddering was undetectable in DNA fragmentation assay, and DNA 3;-OH reactivity was not detected in TUNEL assay. We then examined the role of phosphatidylinositol 3-kinase (PI3-K), an upstream mediator of Akt, on cell survival. In PANC-1 cells infected with adenovirus vector carrying a deletion mutant of the 85-kDa regulatory subunit of PI3-K and in cells treated with PI3-K inhibitor wortmannin, typical DNA laddering was evident in DNA fragmentation assay. In TUNEL assay, nuclear condensation and DNA 3;-OH reactivity was observed in approximately 30% of these cells.The present results indicate that Akt is implicated in cell growth, but not in survival in PANC-1 cells. These results suggest that there may be an alternative survival signal cascade from PI3-K in PANC-1 cells." @default.
• W2000237223 created "2016-06-24" @default.
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• W2000237223 date "2002-01-01" @default.
• W2000237223 modified "2023-10-17" @default.
• W2000237223 title "Role of Akt in Growth and Survival of PANC-1 Pancreatic Cancer Cells" @default.
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• W2000237223 doi "https://doi.org/10.1097/00006676-200201000-00006" @default.
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