Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000237727> ?p ?o ?g. }
- W2000237727 endingPage "e1004185" @default.
- W2000237727 startingPage "e1004185" @default.
- W2000237727 abstract "The challenge of distinguishing genetic drift from selection remains a central focus of population genetics. Time-sampled data may provide a powerful tool for distinguishing these processes, and we here propose approximate Bayesian, maximum likelihood, and analytical methods for the inference of demography and selection from time course data. Utilizing these novel statistical and computational tools, we evaluate whole-genome datasets of an influenza A H1N1 strain in the presence and absence of oseltamivir (an inhibitor of neuraminidase) collected at thirteen time points. Results reveal a striking consistency amongst the three estimation procedures developed, showing strongly increased selection pressure in the presence of drug treatment. Importantly, these approaches re-identify the known oseltamivir resistance site, successfully validating the approaches used. Enticingly, a number of previously unknown variants have also been identified as being positively selected. Results are interpreted in the light of Fisher's Geometric Model, allowing for a quantification of the increased distance to optimum exerted by the presence of drug, and theoretical predictions regarding the distribution of beneficial fitness effects of contending mutations are empirically tested. Further, given the fit to expectations of the Geometric Model, results suggest the ability to predict certain aspects of viral evolution in response to changing host environments and novel selective pressures." @default.
- W2000237727 created "2016-06-24" @default.
- W2000237727 creator A5002278787 @default.
- W2000237727 creator A5005248562 @default.
- W2000237727 creator A5009290437 @default.
- W2000237727 creator A5013735262 @default.
- W2000237727 creator A5014913705 @default.
- W2000237727 creator A5016364777 @default.
- W2000237727 creator A5019389583 @default.
- W2000237727 creator A5020301143 @default.
- W2000237727 creator A5029418807 @default.
- W2000237727 creator A5045858447 @default.
- W2000237727 creator A5049146277 @default.
- W2000237727 creator A5053742951 @default.
- W2000237727 creator A5060608180 @default.
- W2000237727 creator A5064314813 @default.
- W2000237727 creator A5073951600 @default.
- W2000237727 creator A5084547030 @default.
- W2000237727 creator A5087737854 @default.
- W2000237727 creator A5091558661 @default.
- W2000237727 date "2014-02-27" @default.
- W2000237727 modified "2023-10-09" @default.
- W2000237727 title "Influenza Virus Drug Resistance: A Time-Sampled Population Genetics Perspective" @default.
- W2000237727 cites W1516752631 @default.
- W2000237727 cites W1552511499 @default.
- W2000237727 cites W1638753340 @default.
- W2000237727 cites W1789768012 @default.
- W2000237727 cites W1857888447 @default.
- W2000237727 cites W1902600646 @default.
- W2000237727 cites W1942718106 @default.
- W2000237727 cites W1965700662 @default.
- W2000237727 cites W1967579117 @default.
- W2000237727 cites W1972816359 @default.
- W2000237727 cites W1976694080 @default.
- W2000237727 cites W1988057380 @default.
- W2000237727 cites W1988182864 @default.
- W2000237727 cites W1988533731 @default.
- W2000237727 cites W1992115679 @default.
- W2000237727 cites W1998285838 @default.
- W2000237727 cites W1999991771 @default.
- W2000237727 cites W2000295298 @default.
- W2000237727 cites W2001994823 @default.
- W2000237727 cites W2002109952 @default.
- W2000237727 cites W2002815902 @default.
- W2000237727 cites W2004240297 @default.
- W2000237727 cites W2004313038 @default.
- W2000237727 cites W2004778468 @default.
- W2000237727 cites W2007093655 @default.
- W2000237727 cites W2009691179 @default.
- W2000237727 cites W2011882432 @default.
- W2000237727 cites W2015359732 @default.
- W2000237727 cites W2017388616 @default.
- W2000237727 cites W2023115173 @default.
- W2000237727 cites W2024945476 @default.
- W2000237727 cites W2026597085 @default.
- W2000237727 cites W2027398419 @default.
- W2000237727 cites W2032616735 @default.
- W2000237727 cites W2036507199 @default.
- W2000237727 cites W2043823245 @default.
- W2000237727 cites W2044795082 @default.
- W2000237727 cites W2046094044 @default.
- W2000237727 cites W2046745698 @default.
- W2000237727 cites W2053450368 @default.
- W2000237727 cites W2070521125 @default.
- W2000237727 cites W2078368610 @default.
- W2000237727 cites W2079234047 @default.
- W2000237727 cites W2088567145 @default.
- W2000237727 cites W2095952361 @default.
- W2000237727 cites W2099938953 @default.
- W2000237727 cites W2101168080 @default.
- W2000237727 cites W2101777349 @default.
- W2000237727 cites W2103031204 @default.
- W2000237727 cites W2105280626 @default.
- W2000237727 cites W2106773656 @default.
- W2000237727 cites W2107663516 @default.
- W2000237727 cites W2110455575 @default.
- W2000237727 cites W2111152104 @default.
- W2000237727 cites W2114138957 @default.
- W2000237727 cites W2115583744 @default.
- W2000237727 cites W2121145909 @default.
- W2000237727 cites W2121378139 @default.
- W2000237727 cites W2123600031 @default.
- W2000237727 cites W2123690291 @default.
- W2000237727 cites W2126728600 @default.
- W2000237727 cites W2129728733 @default.
- W2000237727 cites W2131700426 @default.
- W2000237727 cites W2139841187 @default.
- W2000237727 cites W2143054572 @default.
- W2000237727 cites W2143271868 @default.
- W2000237727 cites W2143292535 @default.
- W2000237727 cites W2143598835 @default.
- W2000237727 cites W2144658220 @default.
- W2000237727 cites W2157298599 @default.
- W2000237727 cites W2159773237 @default.
- W2000237727 cites W2162174872 @default.
- W2000237727 cites W2165045975 @default.
- W2000237727 cites W2167706324 @default.
- W2000237727 cites W2168268382 @default.