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- W2000238190 endingPage "164" @default.
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- W2000238190 abstract "The field of nanotechnology has recently seen vast advancements in its applications for therapeutic strategy. This technological revolution has led way to nanomedicine, which spurred the development of clever drug delivery designs and ingenious nanovehicles for the monitoring of cellular events in vivo. The clinical implementations of this technology are innumerable and have demonstrated utility as diagnostic tools and fortifying machineries for the mammalian immune system. Recently engineered viral vectors and multi-subunit packaging RNAs have verified stable enough for long-term existence in the physiological environment and therefore reveal unique potential as artificial immunosurveillance devices. Physiological and pathological events recorded by nanodevices could help develop biocatalogs of patients' infection history, frequency of disease, and much more. In this article, we introduce a novel design concept for a multilayer synthetic immune network parallel to the natural immune system; an artificial network of continuously patrolling nanodevices incorporated in the blood and lymphatic systems, and adapted for molecular event recording, anomaly detection, drug delivery, and gene silencing. We also aim to discuss the approaches and advances recently reported in nanomedicine, especially as it pertains to promising viral and RNA-based nanovehicles and their prospective applications for the development of a synthetic immunosurveillance system (SIS). Alternative suggestions and limitations of these technologies are also discussed." @default.
- W2000238190 created "2016-06-24" @default.
- W2000238190 creator A5029618034 @default.
- W2000238190 creator A5031234954 @default.
- W2000238190 creator A5081618191 @default.
- W2000238190 date "2014-11-01" @default.
- W2000238190 modified "2023-09-23" @default.
- W2000238190 title "Synthetic immunosurveillance systems: Nanodevices to monitor physiological events" @default.
- W2000238190 cites W144423133 @default.
- W2000238190 cites W1486369891 @default.
- W2000238190 cites W1529854703 @default.
- W2000238190 cites W1566430503 @default.
- W2000238190 cites W1607819524 @default.
- W2000238190 cites W1730064184 @default.
- W2000238190 cites W1773745624 @default.
- W2000238190 cites W1800005238 @default.
- W2000238190 cites W1964152201 @default.
- W2000238190 cites W1964586095 @default.
- W2000238190 cites W1966026816 @default.
- W2000238190 cites W1966641706 @default.
- W2000238190 cites W1969059363 @default.
- W2000238190 cites W1969989481 @default.
- W2000238190 cites W1970685893 @default.
- W2000238190 cites W1970703666 @default.
- W2000238190 cites W1971915082 @default.
- W2000238190 cites W1972180606 @default.
- W2000238190 cites W1972511696 @default.
- W2000238190 cites W1977387773 @default.
- W2000238190 cites W1980272310 @default.
- W2000238190 cites W1981989535 @default.
- W2000238190 cites W1985687704 @default.
- W2000238190 cites W1986096506 @default.
- W2000238190 cites W1991836284 @default.
- W2000238190 cites W1992086319 @default.
- W2000238190 cites W1992834282 @default.
- W2000238190 cites W1995754005 @default.
- W2000238190 cites W1998744803 @default.
- W2000238190 cites W1998758377 @default.
- W2000238190 cites W2000319267 @default.
- W2000238190 cites W2000348498 @default.
- W2000238190 cites W2000937204 @default.
- W2000238190 cites W2001583023 @default.
- W2000238190 cites W2002148098 @default.
- W2000238190 cites W2005659566 @default.
- W2000238190 cites W2007764764 @default.
- W2000238190 cites W2008408833 @default.
- W2000238190 cites W2008767836 @default.
- W2000238190 cites W2011677296 @default.
- W2000238190 cites W2012017253 @default.
- W2000238190 cites W2012268010 @default.
- W2000238190 cites W2013679212 @default.
- W2000238190 cites W2027707550 @default.
- W2000238190 cites W2029164954 @default.
- W2000238190 cites W2031343644 @default.
- W2000238190 cites W2031742656 @default.
- W2000238190 cites W2031745114 @default.
- W2000238190 cites W2033859126 @default.
- W2000238190 cites W2037234144 @default.
- W2000238190 cites W2039581700 @default.
- W2000238190 cites W2045098215 @default.
- W2000238190 cites W2047311992 @default.
- W2000238190 cites W2050092757 @default.
- W2000238190 cites W2052439439 @default.
- W2000238190 cites W2052638788 @default.
- W2000238190 cites W2055920137 @default.
- W2000238190 cites W2059249141 @default.
- W2000238190 cites W2059990765 @default.
- W2000238190 cites W2061600013 @default.
- W2000238190 cites W2061847163 @default.
- W2000238190 cites W2065282794 @default.
- W2000238190 cites W2067556994 @default.
- W2000238190 cites W2068746444 @default.
- W2000238190 cites W2069810268 @default.
- W2000238190 cites W2072576950 @default.
- W2000238190 cites W2073500768 @default.
- W2000238190 cites W2073550735 @default.
- W2000238190 cites W2076649417 @default.
- W2000238190 cites W2077850544 @default.
- W2000238190 cites W2079903460 @default.
- W2000238190 cites W2079990421 @default.
- W2000238190 cites W2080155742 @default.
- W2000238190 cites W2083014800 @default.
- W2000238190 cites W2083453090 @default.
- W2000238190 cites W2083578787 @default.
- W2000238190 cites W2084019169 @default.
- W2000238190 cites W2087747104 @default.
- W2000238190 cites W2088536552 @default.
- W2000238190 cites W2088542458 @default.
- W2000238190 cites W2091691458 @default.
- W2000238190 cites W2096231594 @default.
- W2000238190 cites W2096569427 @default.
- W2000238190 cites W2097503372 @default.
- W2000238190 cites W2098005365 @default.
- W2000238190 cites W2103758700 @default.
- W2000238190 cites W2106347959 @default.
- W2000238190 cites W2107271062 @default.
- W2000238190 cites W2107762071 @default.
- W2000238190 cites W2108422551 @default.