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• W2000238416 abstract "<b><i>Objective:</i></b> To use paired-pulse transcranial magnetic stimulation (TMS) to investigate cortical excitability in drug-naive patients with partial epilepsy. <b><i>Methods:</i></b> Twenty-one drug-naive patients with partial epilepsy and 15 control subjects were studied. The relaxed threshold to TMS, the central silent period, and the intracortical inhibition/facilitation were measured. Statistics implied cluster analysis methods. Also assessed were the patient interictal EEG epileptiform abnormalities (EAs) on a semiquantitative basis. Then the TMS was contrasted to the clinical and EEG findings, using χ² or Fisher exact tests. <b><i>Results:</i></b> One-third of the patients made up a “pathologic” cluster with a disrupted intracortical inhibition (<i>p</i> < 0.01). Two-thirds had a normal inhibition. Interictal EAs predominated in the pathologic cluster, for frequency (<i>p</i> < 0.04), duration (<i>p</i> < 0.04), and focality (<i>p</i> < 0.02). <b><i>Conclusions:</i></b> Intracortical inhibition, which was impaired in one-third of the patients, reflects γ-aminobutyric acid (GABA) activity within cortical area 4. Defective GABA inhibition is a typical pathogenic factor in partial epilepsy. Transcranial magnetic stimulation proved able to detect it. The weaker cortical inhibition had a direct relation to the severity of interictal epileptiform abnormalities." @default.
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• W2000238416 date "2004-12-13" @default.
• W2000238416 modified "2023-09-26" @default.
• W2000238416 title "Cortical excitability in drug-naive patients with partial epilepsy: A cross-sectional study" @default.
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• W2000238416 doi "https://doi.org/10.1212/01.wnl.0000145770.95990.82" @default.
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