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- W2000239461 abstract "Abstract Hippurate, synthetized from benzoate and glycine in the liver and in the kidney of several species modulates the activity of renal γ-glutamyl-transpeptidase. By this mechanism hippurate interferes with renal intra-luminal ammonia production. Besides, in the rat hippurate serves as a minor substrate for renal ammoniagenesis as well. Hippurate may yield ammonia from its glycine moiety either after cleavage by hippuricase, or after condensation with an aldehyde according to Erlenmeyer's reaction. This reaction results in producing equimolar amounts of ammonia, benzoate and an α-keto acid, thus in a net gain of an acid equivalent. -In order to evaluate variability and extent of renal ammonia production from hippurate in different species, experiments were carried out on isolated tubular segments of the rat and on cortical kidney slices of rat, cow, man and cat. The incubation medium was enriched with J0mmol/1 hippurate spiked with 5% of 15N-hippurate, some of the known inhibitors of hippuricase and γGT as well as glyceraldehyde or propional-dehyde. Factors known to affect hippuricase or γGT did not interfere with renal ammonia production from hippurate, but glyceraldehyde and propionaldehyde (up to 1mmol/1) had a stimulating effect. Renal ammoniagenesis from hippurate as well as production of benzoate was lowest in the cow (∼ 0.1%), amounted to 1–2% in rat and man and reached high values in the cat (up to 15% of the total ammonia production). These results indicate that hippurate could have physiological significance in the renal metabolism of some species." @default.
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- W2000239461 date "1994-07-01" @default.
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- W2000239461 title "Production of Ammonia From Hippurate in the Kidney of Different Species Including Man.an in vitroStudy with15N-Hippurate" @default.
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- W2000239461 doi "https://doi.org/10.1080/00211919408046724" @default.
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