FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000239486> ?p ?o ?g. }

• W2000239486 endingPage "23" @default.
• W2000239486 startingPage "16" @default.
• W2000239486 abstract "Glaucoma is a multifactorial progressive ocular pathology, clinically presenting with damage to the retina and optic nerve, ultimately leading to blindness. Retinal ganglion cell loss in glaucoma ultimately results in vision loss. Vesl/Homer proteins are scaffolding proteins that are critical for maintaining synaptic integrity by clustering, organizing and functionally regulating synaptic proteins. Current anti-glaucoma therapies target IOP as the sole modifiable clinical parameters. Long-term pharmacotherapy and surgical treatment do not prevent gradual visual field loss as the disease progresses, highlighting the need for new complementary, alternative and comprehensive treatment approaches. Vesl/Homer expression was measured in the retinae of DBA/2J mice, a preclinical genetic glaucoma model with spontaneous mutations resulting in a phenotype reminiscent of chronic human pigmentary glaucoma. Vesl/Homer proteins were differentially expressed in the aged, glaucomatous DBA/2J retina, both at the transcriptional and translational level. Immunoreactivity for the long Vesl-1L/Homer 1c isoform, but not of the immediate early gene product Vesl-1S/Homer 1a was increased in the synaptic layers of the retina. This increased protein level of Vesl-1L/Homer 1c was correlated with phenotypes of increased disease severity and a decrease in visual performance. The increased expression of Vesl-1L/Homer 1c in the glaucomatous retina likely results in increased intracellular Ca2+ release through enhancement of synaptic coupling. The ensuing Ca2+ toxicity may thus activate neurodegenerative pathways and lead to the progressive loss of synaptic function in glaucoma. Our data suggest that higher levels of Vesl-1L/Homer 1c generate a more severe disease phenotype and may represent a viable target for therapy development." @default.
• W2000239486 created "2016-06-24" @default.
• W2000239486 creator A5009291181 @default.
• W2000239486 creator A5011305196 @default.
• W2000239486 creator A5031089455 @default.
• W2000239486 creator A5039548100 @default.
• W2000239486 creator A5042493368 @default.
• W2000239486 date "2014-01-01" @default.
• W2000239486 modified "2023-09-23" @default.
• W2000239486 title "Differential up-regulation of Vesl-1/Homer 1 protein isoforms associated with decline in visual performance in a preclinical glaucoma model" @default.
• W2000239486 cites W1553218248 @default.
• W2000239486 cites W1763958744 @default.
• W2000239486 cites W1775749144 @default.
• W2000239486 cites W1949420119 @default.
• W2000239486 cites W1967874462 @default.
• W2000239486 cites W1968883861 @default.
• W2000239486 cites W1977929159 @default.
• W2000239486 cites W1982379134 @default.
• W2000239486 cites W1987599996 @default.
• W2000239486 cites W1990245848 @default.
• W2000239486 cites W1992361696 @default.
• W2000239486 cites W2001989336 @default.
• W2000239486 cites W2002590408 @default.
• W2000239486 cites W2015410192 @default.
• W2000239486 cites W2019372876 @default.
• W2000239486 cites W2019610144 @default.
• W2000239486 cites W2020648460 @default.
• W2000239486 cites W2023682415 @default.
• W2000239486 cites W2024527636 @default.
• W2000239486 cites W2026644592 @default.
• W2000239486 cites W2031958455 @default.
• W2000239486 cites W2040275472 @default.
• W2000239486 cites W2041612070 @default.
• W2000239486 cites W2044050052 @default.
• W2000239486 cites W2045269704 @default.
• W2000239486 cites W2053899262 @default.
• W2000239486 cites W2055820698 @default.
• W2000239486 cites W2060287168 @default.
• W2000239486 cites W2074876991 @default.
• W2000239486 cites W2078341575 @default.
• W2000239486 cites W2078833625 @default.
• W2000239486 cites W2084810632 @default.
• W2000239486 cites W2091711942 @default.
• W2000239486 cites W2107277218 @default.
• W2000239486 cites W2113888956 @default.
• W2000239486 cites W2117421244 @default.
• W2000239486 cites W2121575943 @default.
• W2000239486 cites W2125736391 @default.
• W2000239486 cites W2127057042 @default.
• W2000239486 cites W2138368626 @default.
• W2000239486 cites W2155377690 @default.
• W2000239486 cites W2164762131 @default.
• W2000239486 cites W2169113983 @default.
• W2000239486 doi "https://doi.org/10.1016/j.visres.2013.10.018" @default.
• W2000239486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3890355" @default.
• W2000239486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24219919" @default.
• W2000239486 hasPublicationYear "2014" @default.
• W2000239486 type Work @default.
• W2000239486 sameAs 2000239486 @default.
• W2000239486 citedByCount "12" @default.
• W2000239486 countsByYear W20002394862014 @default.
• W2000239486 countsByYear W20002394862015 @default.
• W2000239486 countsByYear W20002394862016 @default.
• W2000239486 countsByYear W20002394862018 @default.
• W2000239486 countsByYear W20002394862022 @default.
• W2000239486 crossrefType "journal-article" @default.
• W2000239486 hasAuthorship W2000239486A5009291181 @default.
• W2000239486 hasAuthorship W2000239486A5011305196 @default.
• W2000239486 hasAuthorship W2000239486A5031089455 @default.
• W2000239486 hasAuthorship W2000239486A5039548100 @default.
• W2000239486 hasAuthorship W2000239486A5042493368 @default.
• W2000239486 hasBestOaLocation W20002394861 @default.
• W2000239486 hasConcept C118487528 @default.
• W2000239486 hasConcept C169760540 @default.
• W2000239486 hasConcept C2777093970 @default.
• W2000239486 hasConcept C2778527774 @default.
• W2000239486 hasConcept C2780837183 @default.
• W2000239486 hasConcept C71924100 @default.
• W2000239486 hasConcept C86803240 @default.
• W2000239486 hasConceptScore W2000239486C118487528 @default.
• W2000239486 hasConceptScore W2000239486C169760540 @default.
• W2000239486 hasConceptScore W2000239486C2777093970 @default.
• W2000239486 hasConceptScore W2000239486C2778527774 @default.
• W2000239486 hasConceptScore W2000239486C2780837183 @default.
• W2000239486 hasConceptScore W2000239486C71924100 @default.
• W2000239486 hasConceptScore W2000239486C86803240 @default.
• W2000239486 hasLocation W20002394861 @default.
• W2000239486 hasLocation W20002394862 @default.
• W2000239486 hasLocation W20002394863 @default.
• W2000239486 hasLocation W20002394864 @default.
• W2000239486 hasOpenAccess W2000239486 @default.
• W2000239486 hasPrimaryLocation W20002394861 @default.
• W2000239486 hasRelatedWork W2060600735 @default.
• W2000239486 hasRelatedWork W2063987331 @default.
• W2000239486 hasRelatedWork W2119707723 @default.
• W2000239486 hasRelatedWork W2415173924 @default.
• W2000239486 hasRelatedWork W2418193912 @default.
• W2000239486 hasRelatedWork W2803552185 @default.

• next