Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000240015> ?p ?o ?g. }
- W2000240015 endingPage "26" @default.
- W2000240015 startingPage "13" @default.
- W2000240015 abstract "By fusing the CaMKII-inhibitory peptide AIP to GFP, we constructed a specific and effective CaMKII inhibitor, GFP-AIP. Expression of GFP-AIP and/or dominant-inhibitory CaMKIV in cultured neonatal rat spiral ganglion neurons (SGNs) shows that CaMKII and CaMKIV act additively and in parallel to mediate the prosurvival effect of depolarization. Depolarization or expression of constitutively active CaMKII functionally inactivates Bad, indicating that this is one means by which CaMKII promotes neuronal survival. CaMKIV, but not CaMKII, requires CREB to promote SGN survival, consistent with the exclusively nuclear localization of CaMKIV and indicating that the principal prosurvival function of CaMKIV is activation of CREB. Consistent with this, a constitutively active CREB construct that provides a high level of CREB activity promotes SGN survival, although low levels of CREB activity did not do so. Also, in apoptotic SGNs, activation of CREB by depolarization is disabled, presumably as part of a cellular commitment to apoptosis." @default.
- W2000240015 created "2016-06-24" @default.
- W2000240015 creator A5000730759 @default.
- W2000240015 creator A5062493663 @default.
- W2000240015 creator A5075826471 @default.
- W2000240015 creator A5084704164 @default.
- W2000240015 date "2007-09-01" @default.
- W2000240015 modified "2023-09-27" @default.
- W2000240015 title "CaMKII and CaMKIV mediate distinct prosurvival signaling pathways in response to depolarization in neurons" @default.
- W2000240015 cites W1496297920 @default.
- W2000240015 cites W1539043236 @default.
- W2000240015 cites W1547617108 @default.
- W2000240015 cites W1562796888 @default.
- W2000240015 cites W1570784999 @default.
- W2000240015 cites W1580590749 @default.
- W2000240015 cites W1599213556 @default.
- W2000240015 cites W1602481380 @default.
- W2000240015 cites W1606738305 @default.
- W2000240015 cites W1614322283 @default.
- W2000240015 cites W1644197639 @default.
- W2000240015 cites W1675685854 @default.
- W2000240015 cites W1874291746 @default.
- W2000240015 cites W1882516571 @default.
- W2000240015 cites W1964337986 @default.
- W2000240015 cites W1965722126 @default.
- W2000240015 cites W1968725235 @default.
- W2000240015 cites W1973141367 @default.
- W2000240015 cites W1975290731 @default.
- W2000240015 cites W1976062660 @default.
- W2000240015 cites W1976441097 @default.
- W2000240015 cites W1981364887 @default.
- W2000240015 cites W1985223341 @default.
- W2000240015 cites W1987035130 @default.
- W2000240015 cites W1988004907 @default.
- W2000240015 cites W1988181440 @default.
- W2000240015 cites W1989977352 @default.
- W2000240015 cites W1992529363 @default.
- W2000240015 cites W1993779727 @default.
- W2000240015 cites W1995322850 @default.
- W2000240015 cites W1995459135 @default.
- W2000240015 cites W1996024251 @default.
- W2000240015 cites W1999270780 @default.
- W2000240015 cites W1999356709 @default.
- W2000240015 cites W2000304313 @default.
- W2000240015 cites W2002287054 @default.
- W2000240015 cites W2005972504 @default.
- W2000240015 cites W2008622025 @default.
- W2000240015 cites W2012243761 @default.
- W2000240015 cites W2012943066 @default.
- W2000240015 cites W2013671870 @default.
- W2000240015 cites W2015082850 @default.
- W2000240015 cites W2023583278 @default.
- W2000240015 cites W2027377352 @default.
- W2000240015 cites W2027874936 @default.
- W2000240015 cites W2028242823 @default.
- W2000240015 cites W2029524108 @default.
- W2000240015 cites W2030573603 @default.
- W2000240015 cites W2031863862 @default.
- W2000240015 cites W2033529039 @default.
- W2000240015 cites W2038405912 @default.
- W2000240015 cites W2040213449 @default.
- W2000240015 cites W2041478537 @default.
- W2000240015 cites W2048326843 @default.
- W2000240015 cites W2051178710 @default.
- W2000240015 cites W2055847058 @default.
- W2000240015 cites W2056286291 @default.
- W2000240015 cites W2056481979 @default.
- W2000240015 cites W2057559510 @default.
- W2000240015 cites W2060913542 @default.
- W2000240015 cites W2064856877 @default.
- W2000240015 cites W2068827505 @default.
- W2000240015 cites W2069527370 @default.
- W2000240015 cites W2070840393 @default.
- W2000240015 cites W2071158184 @default.
- W2000240015 cites W2073302735 @default.
- W2000240015 cites W2077615436 @default.
- W2000240015 cites W2077750857 @default.
- W2000240015 cites W2088742837 @default.
- W2000240015 cites W2091598446 @default.
- W2000240015 cites W2094063643 @default.
- W2000240015 cites W2094182857 @default.
- W2000240015 cites W2094730070 @default.
- W2000240015 cites W2095435531 @default.
- W2000240015 cites W2097267765 @default.
- W2000240015 cites W2099976535 @default.
- W2000240015 cites W2100097222 @default.
- W2000240015 cites W2100338501 @default.
- W2000240015 cites W2102410706 @default.
- W2000240015 cites W2107100596 @default.
- W2000240015 cites W2112659765 @default.
- W2000240015 cites W2114677291 @default.
- W2000240015 cites W2117834405 @default.
- W2000240015 cites W2123194197 @default.
- W2000240015 cites W2128904039 @default.
- W2000240015 cites W2130837565 @default.
- W2000240015 cites W2136283388 @default.
- W2000240015 cites W2138525727 @default.
- W2000240015 cites W2138718238 @default.