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• W2000240413 abstract "Abstract Homologous recombination is an important mechanism in DNA replication to ensure faithful DNA synthesis and genomic stability. In this study, we investigated the role of XRCC2, a member of the RAD51 paralog family, in cellular recovery from replication arrest via homologous recombination. The protein expression of XRCC2, as well as its binding partner RAD51D, is dramatically increased in S‐ and G 2 ‐phases, suggesting that these proteins function during and after DNA synthesis. XRCC2 mutant irs1 cells exhibit hypersensitivity to hydroxyurea (HU) and are defective in the induction of RAD51 foci after HU treatment. In addition, the HU‐induced chromatin association of RAD51 is deficient in irs1 mutant. Interestingly, irs1 cells are only slightly sensitive to thymidine and able to form intact RAD51 foci in S‐phase cells arrested with thymidine. Irs1 cells showed increased level of chromatin‐bound RAD51 as well as the wild type cells after thymidine treatment. Both HU and thymidine induce γ‐H2AX foci in arrested S‐phase nuclei. These results suggest that XRCC2 is involved in repair of HU‐induced damage, but not thymidine‐induced damage, at the stalled replication forks. Our data suggest that there are at least two sub‐pathways in homologous recombination, XRCC2‐dependent and ‐independent, for repair of stalled replication forks and assembly of RAD51 foci following replication arrest in S‐phase. © 2005 Wiley‐Liss, Inc." @default.
• W2000240413 created "2016-06-24" @default.
• W2000240413 creator A5030967805 @default.
• W2000240413 creator A5070619554 @default.
• W2000240413 date "2005-04-28" @default.
• W2000240413 modified "2023-10-10" @default.
• W2000240413 title "Differential roles of XRCC2 in homologous recombinational repair of stalled replication forks" @default.
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• W2000240413 doi "https://doi.org/10.1002/jcb.20457" @default.
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