FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000241544> ?p ?o ?g. }

• W2000241544 endingPage "3524" @default.
• W2000241544 startingPage "3515" @default.
• W2000241544 abstract "Degradation of the cartilage proteoglycan aggrecan is a key early event in the development of osteoarthritis. Adamalysin with thrombospondin motifs (ADAMTS) -4 and ADAMTS-5 are considered to be the main enzymes responsible for aggrecan breakdown, making them attractive drugs targets. Here we show that calcium pentosan polysulfate (CaPPS), a chemically sulfated xylanopyranose from beechwood, is a multifaceted exosite inhibitor of the aggrecanases and protects cartilage against aggrecan degradation. CaPPS interacts with the noncatalytic spacer domain of ADAMTS-4 and the cysteine-rich domain of ADAMTS-5, blocking activity against their natural substrate aggrecan with inhibitory concentration 50 values of 10-40 nM but only weakly inhibiting hydrolysis of a nonglycosylated recombinant protein substrate. In addition, CaPPS increased cartilage levels of tissue inhibitor of metalloproteinases-3 (TIMP-3), an endogenous inhibitor of ADAMTS-4 and -5. This was due to the ability of CaPPS to block endocytosis of TIMP-3 mediated by low-density lipoprotein receptor-related protein. CaPPS also increased the affinity of TIMP-3 for ADAMTS-4 and -5 by more than 100-fold, improving the efficacy of TIMP-3 as an aggrecanase inhibitor. Studies with TIMP-3-null mouse cartilage indicated that CaPPS inhibition of aggrecan degradation is TIMP-3 dependent. These unique properties make CaPPS a prototypic disease-modifying agent for osteoarthritis." @default.
• W2000241544 created "2016-06-24" @default.
• W2000241544 creator A5025664015 @default.
• W2000241544 creator A5044186566 @default.
• W2000241544 creator A5069262637 @default.
• W2000241544 creator A5072867575 @default.
• W2000241544 creator A5078344230 @default.
• W2000241544 creator A5087969808 @default.
• W2000241544 date "2008-07-16" @default.
• W2000241544 modified "2023-10-16" @default.
• W2000241544 title "Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases" @default.
• W2000241544 cites W1536230526 @default.
• W2000241544 cites W1586971678 @default.
• W2000241544 cites W1588094592 @default.
• W2000241544 cites W1969498803 @default.
• W2000241544 cites W1972453607 @default.
• W2000241544 cites W1988760613 @default.
• W2000241544 cites W1995678491 @default.
• W2000241544 cites W2002771508 @default.
• W2000241544 cites W2005832407 @default.
• W2000241544 cites W2008325045 @default.
• W2000241544 cites W2011227409 @default.
• W2000241544 cites W2012899141 @default.
• W2000241544 cites W2013028754 @default.
• W2000241544 cites W2016426119 @default.
• W2000241544 cites W2017644547 @default.
• W2000241544 cites W2019462131 @default.
• W2000241544 cites W2023952374 @default.
• W2000241544 cites W2025217427 @default.
• W2000241544 cites W2030402726 @default.
• W2000241544 cites W2031854867 @default.
• W2000241544 cites W2032255522 @default.
• W2000241544 cites W2033505090 @default.
• W2000241544 cites W2034919108 @default.
• W2000241544 cites W2040263753 @default.
• W2000241544 cites W2060281247 @default.
• W2000241544 cites W2064944758 @default.
• W2000241544 cites W2078180135 @default.
• W2000241544 cites W2078984524 @default.
• W2000241544 cites W2083533326 @default.
• W2000241544 cites W2086908525 @default.
• W2000241544 cites W2087286230 @default.
• W2000241544 cites W2093394571 @default.
• W2000241544 cites W2093819129 @default.
• W2000241544 cites W2098076093 @default.
• W2000241544 cites W2102884576 @default.
• W2000241544 cites W2119088930 @default.
• W2000241544 cites W2120840387 @default.
• W2000241544 cites W2122751744 @default.
• W2000241544 cites W2133032095 @default.
• W2000241544 cites W2144594417 @default.
• W2000241544 cites W2150828068 @default.
• W2000241544 cites W2168082829 @default.
• W2000241544 cites W36676292 @default.
• W2000241544 cites W4248025115 @default.
• W2000241544 cites W4256533826 @default.
• W2000241544 doi "https://doi.org/10.1096/fj.08-112680" @default.
• W2000241544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2537431" @default.
• W2000241544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18632849" @default.
• W2000241544 hasPublicationYear "2008" @default.
• W2000241544 type Work @default.
• W2000241544 sameAs 2000241544 @default.
• W2000241544 citedByCount "104" @default.
• W2000241544 countsByYear W20002415442012 @default.
• W2000241544 countsByYear W20002415442013 @default.
• W2000241544 countsByYear W20002415442014 @default.
• W2000241544 countsByYear W20002415442015 @default.
• W2000241544 countsByYear W20002415442016 @default.
• W2000241544 countsByYear W20002415442017 @default.
• W2000241544 countsByYear W20002415442018 @default.
• W2000241544 countsByYear W20002415442019 @default.
• W2000241544 countsByYear W20002415442020 @default.
• W2000241544 countsByYear W20002415442021 @default.
• W2000241544 countsByYear W20002415442022 @default.
• W2000241544 countsByYear W20002415442023 @default.
• W2000241544 crossrefType "journal-article" @default.
• W2000241544 hasAuthorship W2000241544A5025664015 @default.
• W2000241544 hasAuthorship W2000241544A5044186566 @default.
• W2000241544 hasAuthorship W2000241544A5069262637 @default.
• W2000241544 hasAuthorship W2000241544A5072867575 @default.
• W2000241544 hasAuthorship W2000241544A5078344230 @default.
• W2000241544 hasAuthorship W2000241544A5087969808 @default.
• W2000241544 hasBestOaLocation W20002415442 @default.
• W2000241544 hasConcept C105702510 @default.
• W2000241544 hasConcept C109523444 @default.
• W2000241544 hasConcept C142724271 @default.
• W2000241544 hasConcept C167814343 @default.
• W2000241544 hasConcept C185592680 @default.
• W2000241544 hasConcept C189165786 @default.
• W2000241544 hasConcept C197534660 @default.
• W2000241544 hasConcept C204787440 @default.
• W2000241544 hasConcept C2776157581 @default.
• W2000241544 hasConcept C2776164576 @default.
• W2000241544 hasConcept C2776224515 @default.
• W2000241544 hasConcept C2778232976 @default.
• W2000241544 hasConcept C2778259572 @default.
• W2000241544 hasConcept C2779335624 @default.
• W2000241544 hasConcept C2780550940 @default.

• next