Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000241906> ?p ?o ?g. }
- W2000241906 endingPage "73" @default.
- W2000241906 startingPage "43" @default.
- W2000241906 abstract "Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues and to distant organs and is the primary cause of cancer morbidity and mortality. In order to complete the metastatic cascade, cancer cells must detach from the primary tumor, intravasate into the circulatory and lymphatic systems, evade immune attack, extravasate at distant capillary beds, and invade and proliferate in distant organs. Currently, several hypotheses have been advanced to explain the origin of cancer metastasis. These involve an epithelial mesenchymal transition, an accumulation of mutations in stem cells, a macrophage facilitation process, and a macrophage origin involving either transformation or fusion hybridization with neoplastic cells. Many of the properties of metastatic cancer cells are also seen in normal macrophages. A macrophage origin of metastasis can also explain the long-standing seed and soil hypothesis and the absence of metastasis in plant cancers. The view of metastasis as a macrophage metabolic disease can provide novel insight for therapeutic management." @default.
- W2000241906 created "2016-06-24" @default.
- W2000241906 creator A5021162065 @default.
- W2000241906 creator A5056666608 @default.
- W2000241906 date "2013-01-01" @default.
- W2000241906 modified "2023-10-14" @default.
- W2000241906 title "On the Origin of Cancer Metastasis" @default.
- W2000241906 cites W103376025 @default.
- W2000241906 cites W1486262144 @default.
- W2000241906 cites W1511948457 @default.
- W2000241906 cites W1512564160 @default.
- W2000241906 cites W1520425169 @default.
- W2000241906 cites W1525574052 @default.
- W2000241906 cites W1636670860 @default.
- W2000241906 cites W1649938880 @default.
- W2000241906 cites W1749138020 @default.
- W2000241906 cites W1767515115 @default.
- W2000241906 cites W1843320504 @default.
- W2000241906 cites W1860580558 @default.
- W2000241906 cites W1877171832 @default.
- W2000241906 cites W1895115148 @default.
- W2000241906 cites W1958912369 @default.
- W2000241906 cites W1964613165 @default.
- W2000241906 cites W1965709929 @default.
- W2000241906 cites W1967304777 @default.
- W2000241906 cites W1968326919 @default.
- W2000241906 cites W1968601680 @default.
- W2000241906 cites W1969722712 @default.
- W2000241906 cites W1969849554 @default.
- W2000241906 cites W1972293641 @default.
- W2000241906 cites W1973308523 @default.
- W2000241906 cites W1973890143 @default.
- W2000241906 cites W1973963010 @default.
- W2000241906 cites W1973995705 @default.
- W2000241906 cites W1974171150 @default.
- W2000241906 cites W1975531580 @default.
- W2000241906 cites W1975815647 @default.
- W2000241906 cites W1976366877 @default.
- W2000241906 cites W1977173914 @default.
- W2000241906 cites W1980093146 @default.
- W2000241906 cites W1982794439 @default.
- W2000241906 cites W1983151431 @default.
- W2000241906 cites W1984092376 @default.
- W2000241906 cites W1986978964 @default.
- W2000241906 cites W1987664183 @default.
- W2000241906 cites W1988295204 @default.
- W2000241906 cites W1990178765 @default.
- W2000241906 cites W1990877801 @default.
- W2000241906 cites W1991705376 @default.
- W2000241906 cites W1991988195 @default.
- W2000241906 cites W1993347836 @default.
- W2000241906 cites W1994429967 @default.
- W2000241906 cites W1994823455 @default.
- W2000241906 cites W1995563574 @default.
- W2000241906 cites W1998736807 @default.
- W2000241906 cites W1999135119 @default.
- W2000241906 cites W2000108021 @default.
- W2000241906 cites W2001258296 @default.
- W2000241906 cites W2001599240 @default.
- W2000241906 cites W2001717792 @default.
- W2000241906 cites W2002646461 @default.
- W2000241906 cites W2004536682 @default.
- W2000241906 cites W2005034776 @default.
- W2000241906 cites W2005457203 @default.
- W2000241906 cites W2006122532 @default.
- W2000241906 cites W2007897263 @default.
- W2000241906 cites W2009230499 @default.
- W2000241906 cites W2010218849 @default.
- W2000241906 cites W2010876644 @default.
- W2000241906 cites W2012569664 @default.
- W2000241906 cites W2012910069 @default.
- W2000241906 cites W2012988902 @default.
- W2000241906 cites W2016135442 @default.
- W2000241906 cites W2017729871 @default.
- W2000241906 cites W2017988722 @default.
- W2000241906 cites W2018607339 @default.
- W2000241906 cites W2020993937 @default.
- W2000241906 cites W2022233074 @default.
- W2000241906 cites W2024298118 @default.
- W2000241906 cites W2027065209 @default.
- W2000241906 cites W2027825395 @default.
- W2000241906 cites W2029185993 @default.
- W2000241906 cites W2029195626 @default.
- W2000241906 cites W2030035194 @default.
- W2000241906 cites W2030644273 @default.
- W2000241906 cites W2032060721 @default.
- W2000241906 cites W2032514371 @default.
- W2000241906 cites W2032982849 @default.
- W2000241906 cites W2033264705 @default.
- W2000241906 cites W2033618342 @default.
- W2000241906 cites W2034269086 @default.
- W2000241906 cites W2035238501 @default.
- W2000241906 cites W2035265540 @default.
- W2000241906 cites W2035722629 @default.
- W2000241906 cites W2037378061 @default.
- W2000241906 cites W2037615462 @default.
- W2000241906 cites W2037977592 @default.
- W2000241906 cites W2038781914 @default.