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- W2000242313 abstract "This article discusses the research which has led to the controversy of Depo-Provera, and delineates the risks discovered as a result of the studies. Questions are raised as to the advisability of the continued use of this drug.Currently Depo-Provera has not been approved by the FDA (Food and Drug Administration) for contraceptive use in the U.S., although USAID is allowed to distribute it for use in population programs in developing countries. The FDA denied Upjohn's petition for approval of the basis of tests showing that Depo-Provera has caused an increased incidence of mammary carcinoma in laboratory dogs. A review of additional tests conducted on laboratory animals, the results of which were not released to the public, indicates that adverse results were withheld from the public by the manufacturer. Tests with laboratory dogs and monkeys have revealed many serious side effects from the drug. Endometrial carcinoma, shortened life expectancy, interference with carbohydrate metabolism, and suppression of immune responses are the most major of these side effects. The immunosuppressive effects make women more vulnerable to infection and also seem to promote malignancy. Exposure to Depo-Provera, as to other progestogens, in utero is associated with an increased risk of congenital malformation in children. In view of the seriousness of the findings, questions are raised as to the advisability of continued contraceptive use of Depo-Provera." @default.
- W2000242313 created "2016-06-24" @default.
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- W2000242313 date "1981-01-08" @default.
- W2000242313 modified "2023-10-05" @default.
- W2000242313 title "Depo-Provera" @default.
- W2000242313 doi "https://doi.org/10.1300/j013v05n02_05" @default.
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