Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000242842> ?p ?o ?g. }
- W2000242842 endingPage "435" @default.
- W2000242842 startingPage "426" @default.
- W2000242842 abstract "The TRPC cation channel family has been implicated in receptor- or phospholipase C (PLC)-mediated Ca2+ entry into animal cells. These channels are present in mammalian sperm and are assigned a role in ZP3-evoked Ca2+ influx that drives acrosome reactions. However, the mechanisms controlling channel activity and coupling Ca2+ entry through these channels to cellular responses are not well understood. A yeast two-hybrid screen was carried out to identify TRPC-interacting proteins that would be candidate regulators or effectors. We identified a novel protein, enkurin, that is expressed at high levels in the testis and vomeronasal organ and at lower levels in selected other tissues. Enkurin interacts with several TRPC proteins (TRPC1, TRPC2, TRPC5, but not TRPC3) and colocalizes with these channels in sperm. Three protein–protein interaction domains were identified in enkurin: a C-terminal region is essential for channel interaction; an IQ motif binds the Ca2+ sensor, calmodulin, in a Ca2+-dependent manner; and a proline-rich N-terminal region contains predicted ligand sequences for SH3 domain proteins, including the SH3 domain of the p85 regulatory subunit of 1-phosphatidylinositol-3-kinase. We suggest that enkurin is an adaptor that functions to localize a Ca2+ sensitive signal transduction machinery in sperm to a Ca2+-permeable ion channel." @default.
- W2000242842 created "2016-06-24" @default.
- W2000242842 creator A5008949342 @default.
- W2000242842 creator A5011018730 @default.
- W2000242842 creator A5033872453 @default.
- W2000242842 creator A5049681051 @default.
- W2000242842 creator A5059431543 @default.
- W2000242842 creator A5091574027 @default.
- W2000242842 date "2004-10-01" @default.
- W2000242842 modified "2023-10-15" @default.
- W2000242842 title "Enkurin is a novel calmodulin and TRPC channel binding protein in sperm" @default.
- W2000242842 cites W1522789903 @default.
- W2000242842 cites W1922120593 @default.
- W2000242842 cites W1960824769 @default.
- W2000242842 cites W1965271485 @default.
- W2000242842 cites W1965661118 @default.
- W2000242842 cites W1968099835 @default.
- W2000242842 cites W1971473766 @default.
- W2000242842 cites W1975421593 @default.
- W2000242842 cites W1980556867 @default.
- W2000242842 cites W1984984177 @default.
- W2000242842 cites W1986588940 @default.
- W2000242842 cites W1986849356 @default.
- W2000242842 cites W1987704449 @default.
- W2000242842 cites W1988336462 @default.
- W2000242842 cites W1988357397 @default.
- W2000242842 cites W1990967709 @default.
- W2000242842 cites W1996182513 @default.
- W2000242842 cites W1999633796 @default.
- W2000242842 cites W2000967883 @default.
- W2000242842 cites W2001406742 @default.
- W2000242842 cites W2001765951 @default.
- W2000242842 cites W2009653889 @default.
- W2000242842 cites W2014999503 @default.
- W2000242842 cites W2024701933 @default.
- W2000242842 cites W2026062772 @default.
- W2000242842 cites W2026653008 @default.
- W2000242842 cites W2038482800 @default.
- W2000242842 cites W2040664792 @default.
- W2000242842 cites W2045358128 @default.
- W2000242842 cites W2048889447 @default.
- W2000242842 cites W2050209915 @default.
- W2000242842 cites W2059883534 @default.
- W2000242842 cites W2067128597 @default.
- W2000242842 cites W2071328400 @default.
- W2000242842 cites W2071348291 @default.
- W2000242842 cites W2072219354 @default.
- W2000242842 cites W2082183844 @default.
- W2000242842 cites W2084560403 @default.
- W2000242842 cites W2085037886 @default.
- W2000242842 cites W2085297137 @default.
- W2000242842 cites W2088060893 @default.
- W2000242842 cites W2093538857 @default.
- W2000242842 cites W2100837269 @default.
- W2000242842 cites W2103609214 @default.
- W2000242842 cites W2121986992 @default.
- W2000242842 cites W2124674257 @default.
- W2000242842 cites W2142742500 @default.
- W2000242842 cites W2153782195 @default.
- W2000242842 cites W2159196853 @default.
- W2000242842 cites W2161440135 @default.
- W2000242842 cites W2162191366 @default.
- W2000242842 cites W2166856535 @default.
- W2000242842 cites W4211007332 @default.
- W2000242842 doi "https://doi.org/10.1016/j.ydbio.2004.07.031" @default.
- W2000242842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15385169" @default.
- W2000242842 hasPublicationYear "2004" @default.
- W2000242842 type Work @default.
- W2000242842 sameAs 2000242842 @default.
- W2000242842 citedByCount "107" @default.
- W2000242842 countsByYear W20002428422012 @default.
- W2000242842 countsByYear W20002428422013 @default.
- W2000242842 countsByYear W20002428422014 @default.
- W2000242842 countsByYear W20002428422015 @default.
- W2000242842 countsByYear W20002428422016 @default.
- W2000242842 countsByYear W20002428422017 @default.
- W2000242842 countsByYear W20002428422018 @default.
- W2000242842 countsByYear W20002428422019 @default.
- W2000242842 countsByYear W20002428422020 @default.
- W2000242842 countsByYear W20002428422021 @default.
- W2000242842 countsByYear W20002428422022 @default.
- W2000242842 countsByYear W20002428422023 @default.
- W2000242842 crossrefType "journal-article" @default.
- W2000242842 hasAuthorship W2000242842A5008949342 @default.
- W2000242842 hasAuthorship W2000242842A5011018730 @default.
- W2000242842 hasAuthorship W2000242842A5033872453 @default.
- W2000242842 hasAuthorship W2000242842A5049681051 @default.
- W2000242842 hasAuthorship W2000242842A5059431543 @default.
- W2000242842 hasAuthorship W2000242842A5091574027 @default.
- W2000242842 hasConcept C155164980 @default.
- W2000242842 hasConcept C167007842 @default.
- W2000242842 hasConcept C170488646 @default.
- W2000242842 hasConcept C170493617 @default.
- W2000242842 hasConcept C181199279 @default.
- W2000242842 hasConcept C196156954 @default.
- W2000242842 hasConcept C29688787 @default.
- W2000242842 hasConcept C49658373 @default.
- W2000242842 hasConcept C55493867 @default.