Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000243412> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2000243412 endingPage "136" @default.
- W2000243412 startingPage "136" @default.
- W2000243412 abstract "The cellular prion protein is expressed in almost all tissues, including the central nervous system and lymphoid tissues. To investigate the effects of the prion protein in lymphoid cells and spleen structure formation, we used prion protein-deficient (Prnp0/0) Zürich I mice generated by inactivation of the Prnp gene. Prnp0/0 mice had decreased lymphocytes, in particular, CD4 T cells and lymphoid tissue inducer (LTi) cells. Decreased CD4 T cells resulted from impaired expression of CCL19 and CCL21 in the spleen rather than altered chemokine receptor CCR7 expression. Importantly, some of the white pulp regions in spleens from Prnp0/0 mice displayed impaired T zone structure as a result of decreased LTi cell numbers and altered expression of the lymphoid tissue-organizing genes lymphotoxin-α and CXCR5, although expression of the lymphatic marker podoplanin and CXCL13 by stromal cells was not affected. In addition, CD3−CD4+IL-7Rα+ LTi cells were rarely detected in impaired white pulp in spleens of these mice. These data suggest that the prion protein is required to form the splenic white pulp structure and for development of normal levels of CD4 T and LTi cells." @default.
- W2000243412 created "2016-06-24" @default.
- W2000243412 creator A5020921201 @default.
- W2000243412 creator A5021554001 @default.
- W2000243412 creator A5036249495 @default.
- W2000243412 creator A5039191725 @default.
- W2000243412 creator A5051954075 @default.
- W2000243412 creator A5057189462 @default.
- W2000243412 date "2011-06-01" @default.
- W2000243412 modified "2023-09-27" @default.
- W2000243412 title "647 THE EFFECTS OF FETAL UNDERNUTRITION ON THE GENE EXPRESSION OF WHITE ADIPOSE TISSUE IN RAT" @default.
- W2000243412 doi "https://doi.org/10.1016/s1567-5688(11)70648-1" @default.
- W2000243412 hasPublicationYear "2011" @default.
- W2000243412 type Work @default.
- W2000243412 sameAs 2000243412 @default.
- W2000243412 citedByCount "0" @default.
- W2000243412 crossrefType "journal-article" @default.
- W2000243412 hasAuthorship W2000243412A5020921201 @default.
- W2000243412 hasAuthorship W2000243412A5021554001 @default.
- W2000243412 hasAuthorship W2000243412A5036249495 @default.
- W2000243412 hasAuthorship W2000243412A5039191725 @default.
- W2000243412 hasAuthorship W2000243412A5051954075 @default.
- W2000243412 hasAuthorship W2000243412A5057189462 @default.
- W2000243412 hasConcept C116484652 @default.
- W2000243412 hasConcept C127801297 @default.
- W2000243412 hasConcept C12823836 @default.
- W2000243412 hasConcept C13373296 @default.
- W2000243412 hasConcept C135576274 @default.
- W2000243412 hasConcept C153911025 @default.
- W2000243412 hasConcept C16930146 @default.
- W2000243412 hasConcept C179744019 @default.
- W2000243412 hasConcept C17991360 @default.
- W2000243412 hasConcept C181152851 @default.
- W2000243412 hasConcept C186382791 @default.
- W2000243412 hasConcept C203014093 @default.
- W2000243412 hasConcept C2776090121 @default.
- W2000243412 hasConcept C2776914184 @default.
- W2000243412 hasConcept C2778049957 @default.
- W2000243412 hasConcept C2778232189 @default.
- W2000243412 hasConcept C2780931953 @default.
- W2000243412 hasConcept C502942594 @default.
- W2000243412 hasConcept C5858377 @default.
- W2000243412 hasConcept C61879462 @default.
- W2000243412 hasConcept C75877943 @default.
- W2000243412 hasConcept C79484868 @default.
- W2000243412 hasConcept C86803240 @default.
- W2000243412 hasConcept C8891405 @default.
- W2000243412 hasConceptScore W2000243412C116484652 @default.
- W2000243412 hasConceptScore W2000243412C127801297 @default.
- W2000243412 hasConceptScore W2000243412C12823836 @default.
- W2000243412 hasConceptScore W2000243412C13373296 @default.
- W2000243412 hasConceptScore W2000243412C135576274 @default.
- W2000243412 hasConceptScore W2000243412C153911025 @default.
- W2000243412 hasConceptScore W2000243412C16930146 @default.
- W2000243412 hasConceptScore W2000243412C179744019 @default.
- W2000243412 hasConceptScore W2000243412C17991360 @default.
- W2000243412 hasConceptScore W2000243412C181152851 @default.
- W2000243412 hasConceptScore W2000243412C186382791 @default.
- W2000243412 hasConceptScore W2000243412C203014093 @default.
- W2000243412 hasConceptScore W2000243412C2776090121 @default.
- W2000243412 hasConceptScore W2000243412C2776914184 @default.
- W2000243412 hasConceptScore W2000243412C2778049957 @default.
- W2000243412 hasConceptScore W2000243412C2778232189 @default.
- W2000243412 hasConceptScore W2000243412C2780931953 @default.
- W2000243412 hasConceptScore W2000243412C502942594 @default.
- W2000243412 hasConceptScore W2000243412C5858377 @default.
- W2000243412 hasConceptScore W2000243412C61879462 @default.
- W2000243412 hasConceptScore W2000243412C75877943 @default.
- W2000243412 hasConceptScore W2000243412C79484868 @default.
- W2000243412 hasConceptScore W2000243412C86803240 @default.
- W2000243412 hasConceptScore W2000243412C8891405 @default.
- W2000243412 hasIssue "1" @default.
- W2000243412 hasLocation W20002434121 @default.
- W2000243412 hasOpenAccess W2000243412 @default.
- W2000243412 hasPrimaryLocation W20002434121 @default.
- W2000243412 hasRelatedWork W2006296682 @default.
- W2000243412 hasRelatedWork W2008029670 @default.
- W2000243412 hasRelatedWork W2029205180 @default.
- W2000243412 hasRelatedWork W2067578167 @default.
- W2000243412 hasRelatedWork W2070511840 @default.
- W2000243412 hasRelatedWork W2100844737 @default.
- W2000243412 hasRelatedWork W2156787360 @default.
- W2000243412 hasRelatedWork W2399211143 @default.
- W2000243412 hasRelatedWork W4245666369 @default.
- W2000243412 hasRelatedWork W4376121166 @default.
- W2000243412 hasVolume "12" @default.
- W2000243412 isParatext "false" @default.
- W2000243412 isRetracted "false" @default.
- W2000243412 magId "2000243412" @default.
- W2000243412 workType "article" @default.