FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000244570> ?p ?o ?g. }

• W2000244570 endingPage "18" @default.
• W2000244570 startingPage "8" @default.
• W2000244570 abstract "The role of amyloid-beta protein (Abeta) in the pathogenesis of Alzheimer's disease (AD) has been widely investigated and amyloid aggregates are considered a major cause of neuronal dysfunction. Increasing evidence has identified a correlation between this protein and the proteasome, the cellular proteolytic machinery, in particular the ubiquitin-proteasome system. The 20S proteasome is the catalytic core of a complex, known as 26S proteasome, and is the main responsible for the clearance of misfolded and oxidized proteins. In this work we have investigated the effects of different assembly states of two major amyloid peptides, Abeta (1-40) and Abeta (1-42) on the 20S proteasome functionality and on the ubiquitin-dependent pathway of protein degradation. In particular, we have tested proteasome activities after Abeta treatment on purified 20S complexes and on lysates of a human neuroblastoma cell line. Our findings show a significant decrease in proteasome activity, more evident in cell lysates than in isolated complexes, and an increased amount of ubiquitin-protein conjugates and of a known proteasome substrate (p27). Furthermore, the altered proteasome functionality is not associated with a decrease in cell viability, but is linked with increased levels of protein oxidation." @default.
• W2000244570 created "2016-06-24" @default.
• W2000244570 creator A5011049890 @default.
• W2000244570 creator A5021902815 @default.
• W2000244570 creator A5025837267 @default.
• W2000244570 creator A5037480197 @default.
• W2000244570 creator A5066126463 @default.
• W2000244570 creator A5067896832 @default.
• W2000244570 date "2008-05-01" @default.
• W2000244570 modified "2023-09-30" @default.
• W2000244570 title "Amyloid peptides in different assembly states and related effects on isolated and cellular proteasomes" @default.
• W2000244570 cites W1538925586 @default.
• W2000244570 cites W1585493541 @default.
• W2000244570 cites W1588296570 @default.
• W2000244570 cites W1598585009 @default.
• W2000244570 cites W1967574915 @default.
• W2000244570 cites W1976449735 @default.
• W2000244570 cites W1986413832 @default.
• W2000244570 cites W1991915276 @default.
• W2000244570 cites W2001591118 @default.
• W2000244570 cites W2004034281 @default.
• W2000244570 cites W2014341627 @default.
• W2000244570 cites W2025714022 @default.
• W2000244570 cites W2034791616 @default.
• W2000244570 cites W2035784397 @default.
• W2000244570 cites W2037322147 @default.
• W2000244570 cites W2039191388 @default.
• W2000244570 cites W2046209153 @default.
• W2000244570 cites W2047428823 @default.
• W2000244570 cites W2048640332 @default.
• W2000244570 cites W2061632343 @default.
• W2000244570 cites W2066284211 @default.
• W2000244570 cites W2072965202 @default.
• W2000244570 cites W2074777317 @default.
• W2000244570 cites W2075428562 @default.
• W2000244570 cites W2082335828 @default.
• W2000244570 cites W2089033608 @default.
• W2000244570 cites W2091403769 @default.
• W2000244570 cites W2093761069 @default.
• W2000244570 cites W2095546314 @default.
• W2000244570 cites W2097965815 @default.
• W2000244570 cites W2105796226 @default.
• W2000244570 cites W2114918609 @default.
• W2000244570 cites W2115270691 @default.
• W2000244570 cites W2123619340 @default.
• W2000244570 cites W2126152332 @default.
• W2000244570 cites W2148026632 @default.
• W2000244570 cites W2148190798 @default.
• W2000244570 cites W2153767421 @default.
• W2000244570 cites W2161844942 @default.
• W2000244570 cites W2165021720 @default.
• W2000244570 cites W2168025729 @default.
• W2000244570 cites W2169152986 @default.
• W2000244570 cites W4293247451 @default.
• W2000244570 cites W83831086 @default.
• W2000244570 doi "https://doi.org/10.1016/j.brainres.2008.03.003" @default.
• W2000244570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18400214" @default.
• W2000244570 hasPublicationYear "2008" @default.
• W2000244570 type Work @default.
• W2000244570 sameAs 2000244570 @default.
• W2000244570 citedByCount "37" @default.
• W2000244570 countsByYear W20002445702012 @default.
• W2000244570 countsByYear W20002445702013 @default.
• W2000244570 countsByYear W20002445702015 @default.
• W2000244570 countsByYear W20002445702016 @default.
• W2000244570 countsByYear W20002445702017 @default.
• W2000244570 countsByYear W20002445702018 @default.
• W2000244570 countsByYear W20002445702019 @default.
• W2000244570 countsByYear W20002445702020 @default.
• W2000244570 countsByYear W20002445702021 @default.
• W2000244570 countsByYear W20002445702022 @default.
• W2000244570 countsByYear W20002445702023 @default.
• W2000244570 crossrefType "journal-article" @default.
• W2000244570 hasAuthorship W2000244570A5011049890 @default.
• W2000244570 hasAuthorship W2000244570A5021902815 @default.
• W2000244570 hasAuthorship W2000244570A5025837267 @default.
• W2000244570 hasAuthorship W2000244570A5037480197 @default.
• W2000244570 hasAuthorship W2000244570A5066126463 @default.
• W2000244570 hasAuthorship W2000244570A5067896832 @default.
• W2000244570 hasConcept C104317684 @default.
• W2000244570 hasConcept C179104552 @default.
• W2000244570 hasConcept C181199279 @default.
• W2000244570 hasConcept C185592680 @default.
• W2000244570 hasConcept C25602115 @default.
• W2000244570 hasConcept C27740335 @default.
• W2000244570 hasConcept C2777633098 @default.
• W2000244570 hasConcept C2781307694 @default.
• W2000244570 hasConcept C2992195973 @default.
• W2000244570 hasConcept C55493867 @default.
• W2000244570 hasConcept C86803240 @default.
• W2000244570 hasConcept C95444343 @default.
• W2000244570 hasConceptScore W2000244570C104317684 @default.
• W2000244570 hasConceptScore W2000244570C179104552 @default.
• W2000244570 hasConceptScore W2000244570C181199279 @default.
• W2000244570 hasConceptScore W2000244570C185592680 @default.
• W2000244570 hasConceptScore W2000244570C25602115 @default.
• W2000244570 hasConceptScore W2000244570C27740335 @default.
• W2000244570 hasConceptScore W2000244570C2777633098 @default.

• next